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  1. No Access

    Article

    Neutralization Versus Reinforcement of Proinflammatory Cytokines to Arrest Autoimmunity in Type 1 Diabetes

    As physiological pathways of intercellular communication produced by all cells, cytokines are involved in the pathogenesis of inflammatory insulitis as well as pivotal mediators of immune homeostasis. Proinfla...

    Ayelet Kaminitz, Shifra Ash, Nadir Askenasy in Clinical Reviews in Allergy & Immunology (2017)

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    Article

    Mechanisms of diabetic autoimmunity: I—the inductive interface between islets and the immune system at onset of inflammation

    The mechanisms of autoimmune reactivity onset in type 1 diabetes (T1D) remain elusive despite extensive experimentation and discussion. We reconsider several key aspects of the early stages of autoimmunity at...

    Nadir Askenasy in Immunologic Research (2016)

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    Article

    Mechanisms of diabetic autoimmunity: II—Is diabetes a central or peripheral disorder of effector and regulatory cells?

    Two competing hypotheses aiming to explain the onset of autoimmune reactions are discussed in the context of genetic and environmental predisposition to type 1 diabetes (T1D). The first hypothesis has evolved ...

    Nadir Askenasy in Immunologic Research (2016)

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    Article

    Lymphopenia is detrimental to therapeutic approaches to type 1 diabetes using regulatory T cells

    One of the therapeutic approaches to type 1 diabetes (T1D) focuses on enhancement of regulatory T cell (Treg) activity, either by adoptive transfer or supplementation of supporting cytokines such as interleuki...

    Shifra Ash, Shai Yarkoni, Nadir Askenasy in Immunologic Research (2014)

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    Article

    Immunotherapy in high-risk chemotherapy-resistant patients with metastatic solid tumors and hematological malignancies using intentionally mismatched donor lymphocytes activated with rIL-2: a phase I study

    The feasibility and safety of immunotherapy mediated by intentionally mismatched rIL-2 activated killer lymphocytes (IMAK) with no prior stem cell engraftment was investigated in patients with advanced chemoth...

    Shimon Slavin, Aliza Ackerstein, Reuven Or… in Cancer Immunology, Immunotherapy (2010)

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    Article

    Graft versus neuroblastoma reaction is efficiently elicited by allogeneic bone marrow transplantation through cytolytic activity in the absence of GVHD

    Continuous efforts are dedicated to develop immunotherapeutic approaches to neuroblastoma (NB), a tumor that relapses at high rates following high-dose conventional cytotoxic therapy and autologous bone marrow...

    Shifra Ash, Vered Gigi, Nadir Askenasy, Ina Fabian… in Cancer Immunology, Immunotherapy (2009)