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Article
Open AccessSuper-strong magnetic field-dominated ion beam dynamics in focusing plasma devices
High energy density physics is the field of physics dedicated to the study of matter and plasmas in extreme conditions of temperature, densities and pressures. It encompasses multiple disciplines such as mater...
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Article
Open AccessEnhancing laser beam performance by interfering intense laser beamlets
Increasing the laser energy absorption into energetic particle beams represents a longstanding quest in intense laser-plasma physics. During the interaction with matter, part of the laser energy is converted i...
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Article
Open AccessA genome-wide association study identifies two novel susceptibility loci and trans population polygenicity associated with bipolar disorder
Genome-wide association studies (GWASs) have identified several susceptibility loci for bipolar disorder (BD) and shown that the genetic architecture of BD can be explained by polygenicity, with numerous varia...
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Article
Open AccessA novel rare variant R292H in RTN4R affects growth cone formation and possibly contributes to schizophrenia susceptibility
Reticulon 4 receptor (RTN4R) plays an essential role in regulating axonal regeneration and plasticity in the central nervous system through the activation of rho kinase, and is located within chromosome 22q11....
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Article
Open AccessRare genetic variants in CX3CR1 and their contribution to the increased risk of schizophrenia and autism spectrum disorders
CX3CR1, a G protein-coupled receptor solely expressed by microglia in the brain, has been repeatedly reported to be associated with neurodevelopmental disorders including schizophrenia (SCZ) and autism spectru...
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Article
Common variants on 2p16.1, 6p22.1 and 10q24.32 are associated with schizophrenia in Han Chinese population
Many schizophrenia susceptibility loci have been identified through genome-wide association studies (GWASs) in European populations. However, until recently, schizophrenia GWASs in non-European populations wer...
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Article
Open Access37th International Symposium on Intensive Care and Emergency Medicine (part 2 of 3)
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High-resolution copy number variation analysis of schizophrenia in Japan
Recent schizophrenia (SCZ) studies have reported an increased burden of de novo copy number variants (CNVs) and identified specific high-risk CNVs, although with variable phenotype expressivity. However, the path...
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Article
Open AccessBoosting laser-ion acceleration with multi-picosecond pulses
Using one of the world most powerful laser facility, we demonstrate for the first time that high-contrast multi-picosecond pulses are advantageous for proton acceleration. By extending the pulse duration from ...
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Article
Open AccessCommon variants at 1p36 are associated with superior frontal gyrus volume
The superior frontal gyrus (SFG), an area of the brain frequently found to have reduced gray matter in patients with schizophrenia, is involved in self-awareness and emotion, which are impaired in schizophreni...
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Article
Molecular genetic evidence for overlap between general cognitive ability and risk for schizophrenia: a report from the Cognitive Genomics consorTium (COGENT)
It has long been recognized that generalized deficits in cognitive ability represent a core component of schizophrenia (SCZ), evident before full illness onset and independent of medication. The possibility of...
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Article
Open AccessGenome-wide association study identifies a potent locus associated with human opioid sensitivity
Opioids, such as morphine and fentanyl, are widely used as effective analgesics for the treatment of acute and chronic pain. In addition, the opioid system has a key role in the rewarding effects of morphine, ...
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Article
Possible association of CUX1 gene polymorphisms with antidepressant response in major depressive disorder
Association between response to antidepressant treatment and genetic polymorphisms was examined in two independent Japanese samples of patients with major depressive disorder (MDD). Genome-wide approach using ...
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Genetic evidence for association between NOTCH4 and schizophrenia supported by a GWAS follow-up study in a Japanese population
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Article
Application of 28Mg for characterization of Mg uptake in rice seedling under different pH conditions
The magnesium (Mg) uptake of rice seedlings treated with different pH solutions was investigated using tracer of 28Mg. The application of 28Mg enabled the determination of Mg uptake amount within 15 min of the di...
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Article
Parental psychopathology and the risk of suicidal behavior in their offspring: results from the World Mental Health surveys
Previous research suggests that parental psychopathology predicts suicidal behavior among offspring; however, the more fine-grained associations between specific parental disorders and distinct stages of the p...
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Article
Analysis of 10 independent samples provides evidence for association between schizophrenia and a SNP flanking fibroblast growth factor receptor 2
We and others have previously reported linkage to schizophrenia on chromosome 10q25–q26 but, to date, a susceptibility gene in the region has not been identified. We examined data from 3606 single-nucleotide p...
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Aberrant DNA methylation associated with bipolar disorder identified from discordant monozygotic twins
To search DNA methylation difference between monozygotic twins discordant for bipolar disorder, we applied a comprehensive genome scan method, methylation-sensitive representational difference analysis (MS-RDA...
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Article
Pituitary adenylate cyclase-activating polypeptide is associated with schizophrenia
Pituitary adenylate cyclase-activating polypeptide (PACAP, ADCYAP1: adenylate cyclase-activating polypeptide 1), a neuropeptide with neurotransmission modulating activity, is a promising schizophrenia candidat...
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Support for association of the PPP3CC gene with schizophrenia
