7 Result(s)

Article

An automated fluorescence videomicroscopy assay for the detection of mitotic catastrophe

Mitotic catastrophe can be defined as a cell death mode that occurs during or shortly after a prolonged/aberrant mitosis, and can show apoptotic or necrotic features. However, conventional procedures for the d...

S Rello-Varona, O Kepp, I Vitale, M Michaud, L Senovilla, M Jemaà… in Cell Death & Disease (2010)

Article

The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1

The inositol 1,4,5-trisphosphate receptor (IP₃R) is a major regulator of apoptotic signaling. Through interactions with members of the Bcl-2 family of proteins, it drives calcium (Ca²⁺) transients from the endopl...

J M Vicencio, C Ortiz, A Criollo, A W E Jones, O Kepp… in Cell Death & Differentiation (2009)

Article

The co-translocation of ERp57 and calreticulin determines the immunogenicity of cell death

The exposure of calreticulin (CRT) on the plasma membrane can precede anthracycline-induced apoptosis and is required for cell death to be perceived as immunogenic. Mass spectroscopy, immunofluorescence and im...

T Panaretakis, N Joza, N Modjtahedi, A Tesniere, I Vitale… in Cell Death & Differentiation (2008)

Article

No death without life: vital functions of apoptotic effectors

As a result of the genetic experiments performed in Caenorhabditis elegans, it has been tacitly assumed that the core proteins of the ‘apoptotic machinery’ (CED-3, -4, -9 and EGL-1) would be solely involved in ce...

L Galluzzi, N Joza, E Tasdemir, M C Maiuri, M Hengartner… in Cell Death & Differentiation (2008)

Article

The molecular archaeology of a mitochondrial death effector: AIF in Drosophila

Apoptosis-inducing factor (AIF) is a phylogenetically conserved redox-active flavoprotein that contributes to cell death and oxidative phosphorylation in Saccharomyces cerevisiae, Caenorhabditis elegans, mouse an...

N Joza, K Galindo, J A Pospisilik, P Benit, M Rangachari… in Cell Death & Differentiation (2008)

Article

Calreticulin exposure is required for the immunogenicity of γ-irradiation and UVC light-induced apoptosis

M Obeid, T Panaretakis, N Joza, R Tufi, A Tesniere… in Cell Death & Differentiation (2007)

Article

The C-terminal moiety of HIV-1 Vpr induces cell death via a caspase-independent mitochondrial pathway

Previous biochemical studies suggested that HIV-1-encoded Vpr may kill cells through an effect on the adenine nucleotide translocase (ANT), thereby causing mitochondrial membrane permeabilization (MMP). Here, ...

T Roumier, H LA Vieira, M Castedo, K F Ferri, P Boya… in Cell Death & Differentiation (2002)