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  1. Article

    Open Access

    N-acetylaspartate catabolism determines cytosolic acetyl-CoA levels and histone acetylation in brown adipocytes

    Histone acetylation depends on the abundance of nucleo-cytoplasmic acetyl-CoA. Here, we present a novel route for cytoplasmic acetyl-CoA production in brown adipocytes. N-acetylaspartate (NAA) is a highly abun...

    A. Prokesch, H. J. Pelzmann, A. R. Pessentheiner, K. Huber… in Scientific Reports (2016)

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  2. Article

    Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet

    Inflammation contributes to both insulin resistance and pancreatic beta cell failure in human type 2 diabetes. Toll-like receptors (TLRs) are highly conserved pattern recognition receptors that coordinate the ...

    J. A. Ehses, D. T. Meier, S. Wueest, J. Rytka, S. Boller, P. Y. Wielinga… in Diabetologia (2010)

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  3. Article

    The molecular archaeology of a mitochondrial death effector: AIF in Drosophila

    Apoptosis-inducing factor (AIF) is a phylogenetically conserved redox-active flavoprotein that contributes to cell death and oxidative phosphorylation in Saccharomyces cerevisiae, Caenorhabditis elegans, mouse an...

    N Joza, K Galindo, J A Pospisilik, P Benit, M Rangachari… in Cell Death & Differentiation (2008)

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