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Article
The accumulation of IGF-I in kidneys of streptozotocin-diabetic adult rats is not associated with elevated plasma GH or IGF-I levels
Nephropathy is a major complication of diabetes mellitus and is associated with expansion of the mesangium and an increase in kidney size in both humans and rats. Interestingly, early kidney enlargement occurs...
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Article
Modulation of brain insulin-like growth factor I (IGF-I) binding sites and hypothalamic GHRH and somatostatin levels by exogenous growth hormone and IGF-I in juvenile rats
The effect of exogenous growth hormone (GH) and insulin-like growth factor I (IGF-I) on brain IGF-I binding sites (IGF-IR), and on the levels of growth hormone-releasing hormone (GHRH) and somatostatin was stu...
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Article
Transdermal Delivery of Human Growth Hormone Through RF-Microchannels
To evaluate the bioavailability and bioactivity of human growth hormone (hGH) delivered transdermally through microchannels (MCs) in the skin created by radio-frequency (RF) ablation.
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Article
Leptin regulates chondrogenic differentiation in ATDC5 cell-line through JAK/STAT and MAPK pathways
Leptin, the satiety hormone, has been found to affect growth-plate cartilage development. In the present study, some of the signal transduction pathways that mediate leptin signaling in the ATDC5 chondrogenic ...
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Article
A novel loss-of-function mutation in OTX2 in a patient with anophthalmia and isolated growth hormone deficiency
Heterozygous mutations of the gene encoding transcription factor OTX2 were recently shown to be responsible for ocular as well as pituitary abnormalities. Here, we describe a patient with unilateral anophthalmia ...
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Chapter
Gonadotropin-Releasing Hormone Agonists and Sexual Growth in Precocious, Early, and Normal Puberty
Gonadotropin-releasing hormone agonists are considered the treatment of choice for central precocious puberty. They are also administered for postponing puberty in short children with a poor final height progn...
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Chapter
Nutritional-Induced Longitudinal Catch-Up Growth: A Focus on the Growth Plate, Growth-Related Genes, Autophagy, mTOR, and microRNAs
The association between nutrition and linear growth in children is well accepted: the growth of the human skeleton requires an adequate supply of many different nutritional factors and a close relationship exi...
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Article
Spontaneous Normalization of Anti-Tissue Transglutaminase Antibody Levels Is Common in Children with Type 1 Diabetes Mellitus
The prevalence of celiac disease among type 1 diabetes mellitus (T1DM) patients is 5–10 times higher than in the general population. Thus, evaluation of celiac serology is indicated at diagnosis of T1DM and on...
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Article
Short and tall stature: a new paradigm emerges
Linear growth (that is, gain in height) is determined by the rate of growth plate chondrogenesis
Short stat...
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Article
Open AccessClosed-loop glucose control in young people with type 1 diabetes during and after unannounced physical activity: a randomised controlled crossover trial
Hypoglycaemia during and after exercise remains a challenge. The present study evaluated the safety and efficacy of closed-loop insulin delivery during unannounced (to the closed-loop algorithm) afternoon phys...
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Article
Type 1 diabetes mellitus management in young children: implementation of current technologies
The use of advanced technologies for diabetes management is on the rise among pediatric patients with type 1 diabetes (T1D). Continuous subcutaneous insulin infusion (CSII), continuous glucose monitoring, pred...
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Article
Insulin dose optimization using an automated artificial intelligence-based decision support system in youths with type 1 diabetes
Despite the increasing adoption of insulin pumps and continuous glucose monitoring devices, most people with type 1 diabetes do not achieve their glycemic goals1. This could be related to a lack of expertise or i...
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Article
Diabetes ketoacidosis recovery in youth with newly diagnosed and established type 1 diabetes
The objective of this study was to describe the differences in metabolic parameters and in time to recovery from diabetes ketoacidosis (DKA), between children and adolescents with newly diagnosed diabetes comp...
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Article
Changes in body mass index in children and adolescents in Israel during the COVID-19 pandemic
The current coronavirus disease 2019 (COVID-19) pandemic has health, social, and economic implications. Our primary objective was to evaluate changes in body mass index (BMI) from the pre-pandemic to COVID-19 ...
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Article
Exacerbation of disordered eating behaviors in adolescents with type 1 diabetes during the COVID-19 pandemic
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Exacerbation of disordered eating behaviors in adolescents with type 1 diabetes during the COVID-19 pandemic: reply
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Article
Optic pathway glioma and endocrine disorders in patients with and without NF1
Optic pathway gliomas (OPGs) are classified by anatomic location and the association with neurofibromatosis type 1 (NF1). Children with OPGs face sequelae related to tumor location and treatment modalities. We...
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Article
Gonadotropin-releasing hormone analogs treatment in girls with central precocious puberty and early fast puberty
Gonadotropin-releasing hormone analog (GnRHa) is the standard treatment for children with central precocious puberty (CPP). We assessed efficacy and safety of GnRHa treatment in girls with CPP and early fast p...
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Article
Open AccessConsensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 type 1 diabetes
Given the proven benefits of screening to reduce diabetic ketoacidosis (DKA) likelihood at the time of stage 3 type 1 diabetes diagnosis, and emerging availability of therapy to delay disease progression, type...