19 Result(s)

Article

Gonadotropin-releasing hormone analogs treatment in girls with central precocious puberty and early fast puberty

Gonadotropin-releasing hormone analog (GnRHa) is the standard treatment for children with central precocious puberty (CPP). We assessed efficacy and safety of GnRHa treatment in girls with CPP and early fast p...

Leiat Lerman, Michal Yackobovitch-Gavan, Moshe Phillip… in Pediatric Research (2024)

Article

Optic pathway glioma and endocrine disorders in patients with and without NF1

Optic pathway gliomas (OPGs) are classified by anatomic location and the association with neurofibromatosis type 1 (NF1). Children with OPGs face sequelae related to tumor location and treatment modalities. We...

Merav Gil Margolis, Michal Yackobovitz-Gavan, Helen Toledano… in Pediatric Research (2023)

Article

Diabetes ketoacidosis recovery in youth with newly diagnosed and established type 1 diabetes

The objective of this study was to describe the differences in metabolic parameters and in time to recovery from diabetes ketoacidosis (DKA), between children and adolescents with newly diagnosed diabetes comp...

Keren Smuel-Zilberberg, Shlomit Shalitin, Michal Yackobovitch-Gavan… in Pediatric Research (2022)

Article

Insulin dose optimization using an automated artificial intelligence-based decision support system in youths with type 1 diabetes

Despite the increasing adoption of insulin pumps and continuous glucose monitoring devices, most people with type 1 diabetes do not achieve their glycemic goals¹. This could be related to a lack of expertise or i...

Revital Nimri, Tadej Battelino, Lori M. Laffel, Robert H. Slover… in Nature Medicine (2020)

Article

Type 1 diabetes mellitus management in young children: implementation of current technologies

The use of advanced technologies for diabetes management is on the rise among pediatric patients with type 1 diabetes (T1D). Continuous subcutaneous insulin infusion (CSII), continuous glucose monitoring, pred...

Michal Nevo-Shenker, Moshe Phillip, Revital Nimri, Shlomit Shalitin in Pediatric Research (2020)

Article

Short and tall stature: a new paradigm emerges

Article

Spontaneous Normalization of Anti-Tissue Transglutaminase Antibody Levels Is Common in Children with Type 1 Diabetes Mellitus

The prevalence of celiac disease among type 1 diabetes mellitus (T1DM) patients is 5–10 times higher than in the general population. Thus, evaluation of celiac serology is indicated at diagnosis of T1DM and on...

Orith Waisbourd-Zinman, Iva Hojsak, Yoram Rosenbach… in Digestive Diseases and Sciences (2012)

Chapter

Gonadotropin-Releasing Hormone Agonists and Sexual Growth in Precocious, Early, and Normal Puberty

Gonadotropin-releasing hormone agonists are considered the treatment of choice for central precocious puberty. They are also administered for postponing puberty in short children with a poor final height progn...

Liora Lazar… in Handbook of Growth and Growth Monitoring in Health and Disease (2012)

Chapter

Nutritional-Induced Longitudinal Catch-Up Growth: A Focus on the Growth Plate, Growth-Related Genes, Autophagy, mTOR, and microRNAs

The association between nutrition and linear growth in children is well accepted: the growth of the human skeleton requires an adequate supply of many different nutritional factors and a close relationship exi...

Galia Gat-Yablonski, Moshe Phillip in Handbook of Growth and Growth Monitoring i… (2012)

Article

A novel loss-of-function mutation in OTX2 in a patient with anophthalmia and isolated growth hormone deficiency

Heterozygous mutations of the gene encoding transcription factor OTX2 were recently shown to be responsible for ocular as well as pituitary abnormalities. Here, we describe a patient with unilateral anophthalmia ...

Liat Ashkenazi-Hoffnung, Yael Lebenthal, Alexander W. Wyatt… in Human Genetics (2010)

Article

Leptin regulates chondrogenic differentiation in ATDC5 cell-line through JAK/STAT and MAPK pathways

Leptin, the satiety hormone, has been found to affect growth-plate cartilage development. In the present study, some of the signal transduction pathways that mediate leptin signaling in the ATDC5 chondrogenic ...

Miri Ben-Eliezer, Moshe Phillip, Galia Gat-Yablonski in Endocrine (2007)

Article

Transdermal Delivery of Human Growth Hormone Through RF-Microchannels

To evaluate the bioavailability and bioactivity of human growth hormone (hGH) delivered transdermally through microchannels (MCs) in the skin created by radio-frequency (RF) ablation.

Galit Levin, Amikam Gershonowitz, Hagit Sacks, Meir Stern… in Pharmaceutical Research (2005)

Article

Modulation of brain insulin-like growth factor I (IGF-I) binding sites and hypothalamic GHRH and somatostatin levels by exogenous growth hormone and IGF-I in juvenile rats

The effect of exogenous growth hormone (GH) and insulin-like growth factor I (IGF-I) on brain IGF-I binding sites (IGF-IR), and on the levels of growth hormone-releasing hormone (GHRH) and somatostatin was stu...

Rina Eshet, Irit Gil-Ad, Olga Apelboym, Yael Segev… in Journal of Molecular Neuroscience (2004)

Article

The accumulation of IGF-I in kidneys of streptozotocin-diabetic adult rats is not associated with elevated plasma GH or IGF-I levels

Nephropathy is a major complication of diabetes mellitus and is associated with expansion of the mesangium and an increase in kidney size in both humans and rats. Interestingly, early kidney enlargement occurs...

Moshe Phillip, Yael Segeve, Amnon Zung, Avinoam A. Kowarski, Haim Werner… in Endocrine (1995)