7 Result(s)
within
Moritz J. Rossner
Psychiatry
-
Article
Open AccessExtracellular vesicle approach to major psychiatric disorders
Over the last few years, extracellular vesicles (EVs) have received increasing attention as potential non-invasive diagnostic and therapeutic biomarkers for various diseases. The interest in EVs is related to ...
-
Article
Open AccessComparative serum proteomic analysis of a selected protein panel in individuals with schizophrenia and bipolar disorder and the impact of genetic risk burden on serum proteomic profiles
The diagnostic criteria for schizophrenia (SCZ) and bipolar disorder (BD) are based on clinical assessments of symptoms. In this pilot study, we applied high-throughput antibody-based protein profiling to seru...
-
Article
Open AccessSpironolactone alleviates schizophrenia-related reversal learning in Tcf4 transgenic mice subjected to social defeat
Cognitive deficits are a hallmark of schizophrenia, for which no convincing pharmacological treatment option is currently available. Here, we tested spironolactone as a repurposed compound in Tcf4 transgenic m...
-
Article
Open AccessPolygenic burden associated to oligodendrocyte precursor cells and radial glia influences the hippocampal volume changes induced by aerobic exercise in schizophrenia patients
Hippocampal volume decrease is a structural hallmark of schizophrenia (SCZ), and convergent evidence from postmortem and imaging studies suggests that it may be explained by changes in the cytoarchitecture of ...
-
Article
Open AccessStudying and modulating schizophrenia-associated dysfunctions of oligodendrocytes with patient-specific cell systems
Postmortem studies in patients with schizophrenia (SCZ) have revealed deficits in myelination, abnormalities in myelin gene expression and altered numbers of oligodendrocytes in the brain. However, gaining mec...
-
Article
Data calibration and reduction allows to visualize behavioural profiles of psychosocial influences in mice towards clinical domains
Psychosocial stress—particularly in combination with genetic vulnerability—is a critical environmental risk factor for psychiatric diseases in humans. Isolation rearing (IR) and social defeat (SD) paradigms mo...
-
Article
Open AccessStructural synaptic elements are differentially regulated in superior temporal cortex of schizophrenia patients
Inaccurate wiring and synaptic pathology appear to be major hallmarks of schizophrenia. A variety of gene products involved in synaptic neurotransmission and receptor signaling are differentially expressed in ...
