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Open AccessDeconstructing depression by machine learning: the POKAL-PSY study
Unipolar depression is a prevalent and disabling condition, often left untreated. In the outpatient setting, general practitioners fail to recognize depression in about 50% of cases mainly due to somatic comor...
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Open AccessCell type-specific polygenic burden modulates exercise effects in schizophrenia patients: further evidence on volumes of hippocampal subfields
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Open AccessPredictors of adherence to exercise interventions in people with schizophrenia
Exercise interventions are nowadays considered as effective add-on treatments in people with schizophrenia but are usually associated with high dropout rates. Therefore, the present study investigated potentia...
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Open AccessAssociation of polygenic score and the involvement of cholinergic and glutamatergic pathways with lithium treatment response in patients with bipolar disorder
Lithium is regarded as the first-line treatment for bipolar disorder (BD), a severe and disabling mental health disorder that affects about 1% of the population worldwide. Nevertheless, lithium is not consiste...
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New treatment strategies for mental health
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Open AccessCellular pathology in the limbic system in schizophrenia
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Open AccessReduced cortical neuron number and neuron density in schizophrenia with focus on area 24: a post-mortem case–control study
Structural and functional abnormalities of the anterior cingulate cortex (ACC) have frequently been identified in schizophrenia. Alterations of von Economo neurons (VENs), a class of specialized projection neu...
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Open AccessTreatment of negative symptoms in schizophrenia: a challenge for clinical research
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Open AccessAssociations of psychiatric disease and ageing with FKBP5 expression converge on superficial layer neurons of the neocortex
Identification and characterisation of novel targets for treatment is a priority in the field of psychiatry. FKBP5 is a gene with decades of evidence suggesting its pathogenic role in a subset of psychiatric pati...
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Open AccessNeurodevelopmental disturbances in schizophrenia: evidence from genetic and environmental factors
Since more than 3 decades, schizophrenia (SZ) has been regarded as a neurodevelopmental disorder. The neurodevelopmental hypothesis proposes that SZ is associated with genetic and environmental risk factors, w...
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Living Reference Work Entry In depth
Neurobiology of Schizophrenia
The last two decades have seen a revolution in the development of molecular and cellular neurobiology and improvement of neuroimaging methods. Large-scale genome-wide association studies have identified about ...
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Open AccessComparative serum proteomic analysis of a selected protein panel in individuals with schizophrenia and bipolar disorder and the impact of genetic risk burden on serum proteomic profiles
The diagnostic criteria for schizophrenia (SCZ) and bipolar disorder (BD) are based on clinical assessments of symptoms. In this pilot study, we applied high-throughput antibody-based protein profiling to seru...
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Open AccessPost-mortem gene expression of calcium channels Cav1.2 and Cav1.3 in schizophrenia
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Open AccessAssociation between aerobic fitness and the functional connectome in patients with schizophrenia
Schizophrenia is accompanied by widespread alterations in static functional connectivity associated with symptom severity and cognitive deficits. Improvements in aerobic fitness have been demonstrated to ameli...
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Open AccessSpironolactone alleviates schizophrenia-related reversal learning in Tcf4 transgenic mice subjected to social defeat
Cognitive deficits are a hallmark of schizophrenia, for which no convincing pharmacological treatment option is currently available. Here, we tested spironolactone as a repurposed compound in Tcf4 transgenic m...
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Open AccessFitness is positively associated with hippocampal formation subfield volumes in schizophrenia: a multiparametric magnetic resonance imaging study
Hippocampal formation (HF) volume loss is a well-established finding in schizophrenia, with select subfields, such as the cornu ammonis and dentate gyrus, being particularly vulnerable. These morphologic alter...
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Open AccessAssociations between aerobic fitness, negative symptoms, cognitive deficits and brain structure in schizophrenia—a cross-sectional study
Negative symptoms and cognitive deficits are common in individuals with schizophrenia, greatly affect their outcome, and have been associated with alterations in cerebral gray and white matter volume (GMV, WMV...
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Open AccessFailed regeneration and inflammation in schizophrenia: two sides of the same coin?
More than 100 years after its conceptual definition as ‘Dementia Praecox’ by Emil Kraepelin, which was changed to schizophrenia by Eugen Bleuler, this is still a serious and debilitating psychiatric illness. T...
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Open AccessAerobic exercise in severe mental illness: requirements from the perspective of sports medicine
Major depression, bipolar disorder, and schizophrenia are severe mental illnesses. Despite receiving psychopharmacological and psychosocial treatments, about half of patients develop a chronic course with resi...
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Open AccessSex-dependent effects of long-term clozapine or haloperidol medication on red blood cells and liver iron metabolism in Sprague Dawley rats as a model of metabolic syndrome
Patients with liver diseases often have some form of anemia. Hematological dyscrasias are known side effects of antipsychotic drug medication and the occurrence of agranulocytosis under clozapine is well descr...
