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Open AccessDeciphering the roles of triiodothyronine (T3) and thyroid-stimulating hormone (TSH) on cardiac electrical remodeling in clinical and experimental hypothyroidism
Hypothyroidism is the most frequent endocrine pathology. Although clinical or overt hypothyroidism has been traditionally associated to low T3 / T4 and high thyrotropin (TSH) circulating levels, other forms ex...
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Open AccessKv1.3 Channel Blockade Improves Inflammatory Profile, Reduces Cardiac Electrical Remodeling, and Prevents Arrhythmia in Type 2 Diabetic Rats
Kv1.3 channel regulates the activity of lymphocytes, macrophages, or adipose tissue and its blockade reduces inflammatory cytokine secretion and improves insulin sensitivity in animals with metabolic syndrome ...
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Cellular Mechanism Underlying the Misfunction of Cardiac Ionic Channels in Diabetes
The alterations observed in the ECG of diabetic patients correspond to alterations in the repolarizing currents of the cardiac action potential. Diabetes affects the amplitude and kinetics of most of the potas...
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Post-translational modifications regulate the ticking of the circadian clock
Post-translational modifications are as, or even more, important than transcriptional regulation to finely tune circadian rhythms. Oscillations in period (PER)...
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Restoration of cardiac transient outward potassium current by norepinephrine in diabetic rats
In cardiac ventricle, the density of the transient outward potassium current, I to, is clearly related to sympathetic nervous system integrity. This sympathetic regulation of I to
