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Article
Open AccessClinical application of a lung cancer organoid (tumoroid) culture system
Despite high expectations for lung tumoroids, they have not been applied in the clinic due to the difficulty of their long-term culture. Here, however, using AO (airway organoid) media developed by the Clevers...
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Article
An EGFR ligand promotes EGFR-mutant but not KRAS-mutant lung cancer in vivo
EGFR ligands (e.g., EGF and TGFA) have been shown to be clinically associated with poor survival in lung cancer. Since TGFA itself initiates autochthonous tumors in liver, breast, and pancreas but not in the l...
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Protocol
Single-Cell Transcriptome Analysis Using SINCERA Pipeline
Genome-scale single-cell biology has recently emerged as a powerful technology with important implications for both basic and medical research. There are urgent needs for the development of computational metho...