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  1. Article

    Open Access

    Clinical application of a lung cancer organoid (tumoroid) culture system

    Despite high expectations for lung tumoroids, they have not been applied in the clinic due to the difficulty of their long-term culture. Here, however, using AO (airway organoid) media developed by the Clevers...

    Etsuko Yokota, Miki Iwai, Takuro Yukawa, Masakazu Yoshida in npj Precision Oncology (2021)

  2. No Access

    Article

    An EGFR ligand promotes EGFR-mutant but not KRAS-mutant lung cancer in vivo

    EGFR ligands (e.g., EGF and TGFA) have been shown to be clinically associated with poor survival in lung cancer. Since TGFA itself initiates autochthonous tumors in liver, breast, and pancreas but not in the l...

    Koichi Tomoshige, Minzhe Guo, Tomoshi Tsuchiya, Takuya Fukazawa in Oncogene (2018)

  3. No Access

    Protocol

    Single-Cell Transcriptome Analysis Using SINCERA Pipeline

    Genome-scale single-cell biology has recently emerged as a powerful technology with important implications for both basic and medical research. There are urgent needs for the development of computational metho...

    Minzhe Guo, Yan Xu in Transcriptome Data Analysis (2018)