-
Article
Open AccessEstablishment and characterization of novel high mucus-producing lung tumoroids derived from a patient with pulmonary solid adenocarcinoma
Among mucus-producing lung cancers, invasive mucinous adenocarcinoma of the lung is a rare and unique subtype of pulmonary adenocarcinoma. Notably, mucus production may also be observed in the five subtypes of...
-
Article
Open AccessTransforming tumoroids derived from ALK-positive pulmonary adenocarcinoma to squamous cell carcinoma in vivo
Approximately 3–5% of non-small cell lung cancers (NSCLC) harbor ALK fusion genes and may be responsive to anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors. There are only a few reports on cell lines w...
-
Article
Open AccessBioelectrical impedance analysis for perioperative water management in adult cardiovascular valve disease surgery
Bioelectrical impedance analysis (BIA) has been used recently to measure the body water of patients with acute heart failure. We used BIA in this study to better understand, and possibly identify a predictive ...
-
Article
Open AccessClinical application of a lung cancer organoid (tumoroid) culture system
Despite high expectations for lung tumoroids, they have not been applied in the clinic due to the difficulty of their long-term culture. Here, however, using AO (airway organoid) media developed by the Clevers...
-
Article
Open AccessPneumatosis intestinalis after gefitinib therapy for pulmonary adenocarcinoma: a case report
Pneumatosis intestinalis (PI) is defined as the presence of gas in the bowel wall and is a relatively rare finding. PI has been associated with various pathological conditions and medications. Although several...
-
Article
MHC class I chain-related molecule A and B expression is upregulated by cisplatin and associated with good prognosis in patients with non-small cell lung cancer
MHC class I chain-related molecule A and B (MICA/B) are NK group 2 member D (NKG2D) ligands, which are broadly expressed in transformed cells. Both DNA damage-induced ataxia-telangiectasia-mutated (ATM)- and ...
-
Article
Open AccessClinical significance of dual-time-point 18F-FDG PET imaging in resectable non-small cell lung cancer
The maximal standardized uptake value (SUVmax) of pulmonary lesions on dual-time-point (DTP) fluorodeoxyglucose positron emission tomography (FDG-PET) has been shown to be useful for differentiation between ma...
-
Article
Open AccessCyclooxygenase-2 expression is a prognostic biomarker for non-small cell lung cancer patients treated with adjuvant platinum-based chemotherapy
Adjuvant chemotherapy after the resection of stage IB-IIIA non-small cell lung cancer (NSCLC) is now the standard of care based on large-scale phase III trials and a meta-analysis. However, chemotherapy has pl...
-
Article
Open AccessDifference in prognostic values of maximal standardized uptake value on fluorodeoxyglucose-positron emission tomography and cyclooxygenase-2 expression between lung adenocarcinoma and squamous cell carcinoma
The maximal standardized uptake value (SUVmax) on fluorodeoxyglucose-positron emission tomography (FDG-PET) for primary tumors is correlated with clinicopathological and prognostic factors in patients with non...
-
Article
Open AccessA case report of intrapulmonary schwannoma
A 38-year-old man without any symptoms was admitted to our institution because of an abnormal shadow found incidentally on a chest X-ray. Chest computed tomography showed a round mass in the lingular segment o...
-
Article
Heterogeneity of the EGFR mutation status between the primary tumor and metastatic lymph node and the sensitivity to EGFR tyrosine kinase inhibitor in non-small cell lung cancer
The purpose of this study was to clarify the distribution of epidermal growth factor receptor (EGFR) mutations between primary tumors (PT) and metastatic lymph node (MLN) in patients with resected non-small cell ...
-
Article
Unknown primary large cell neuroendocrine carcinoma (LCNEC) in the mediastinum
Unknown primary large cell neuroendocrine carcinoma (LCNEC) in the mediastinum is extremely rare. In this report, we present a case of a 53-year-old man with superior vena cava (SVC) syndrome who developed LCN...
-
Article
Role of 2-[18F]fluoro-2-deoxyglucose positron emission tomography in preoperative management of solid-type small-sized lung cancer
2-[18F]Fluoro-2-deoxyglucose positron emission tomography (FDG-PET) is routinely used for the diagnosis of primary lung cancer. However, the role of FDG-PET in the diagnosis and staging of small-sized lung can...
-
Article
Open AccessMembrane-bound estrogen receptor-α expression and epidermal growth factor receptor mutation are associated with a poor prognosis in lung adenocarcinoma patients
The purpose of this study is to clarify the correlations between the expression of membrane-bound estrogen receptor-α (mERα) and epidermal growth factor receptor (EGFR) mutation and clinicopathological factors...
-
Chapter and Conference Paper
Three Cases of Total Aortic Replacement for Marfan Syndrome
Marfan syndrome is a connective tissue metabolic disorder which descends as autosomal dominant manner. Patients with Marfan syndrome suffer from various diseases such as aortic aneurysm or aortic dissection. W...
-
Chapter and Conference Paper
Late Outcome of Extra-anatomic Bypass for Infected Abdominal Aortic Aneurysm
We examined the surgical result and late outcome of the extra-anatomic bypass for infected abdominal aortic aneurysm. Seven patients underwent operations in our institution and were male with a mean age of 68....
