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  1. Article

    Open Access

    Identification of the atypical cadherin FAT1 as a novel glypican-3 interacting protein in liver cancer cells

    Glypican-3 (GPC3) is a cell surface heparan sulfate proteoglycan that is being evaluated as an emerging therapeutic target in hepatocellular carcinoma (HCC). GPC3 has been shown to interact with several extrac...

    Panpan Meng, Yi-Fan Zhang, Wangli Zhang, **n Chen, Tong Xu, Sheng Hu… in Scientific Reports (2021)

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    Article

    Immunotoxin targeting glypican-3 regresses liver cancer via dual inhibition of Wnt signalling and protein synthesis

    Glypican-3 is a cell surface glycoprotein that associates with Wnt in liver cancer. We develop two antibodies targeting glypican-3, HN3 and YP7. The first antibody recognizes a functional epitope and inhibits ...

    Wei Gao, Zhewei Tang, Yi-Fan Zhang, Mingqian Feng, Min Qian… in Nature Communications (2015)