-
Article
Simultaneous Computation of Traction Power Supply System Using State-Space Nodal Grou** Method
The paper presents the real-time simulation of DC traction power supply systems for electric trains. It works as a virtualization solution for DC traction power supply systems, facilitating the testing of real...
-
Article
Half-Bridge Diode-Clamped Four-Level LLC Resonant Converter with Pulse-Amplitude-Modulation for Railway Applications
In this paper, we propose a half-bridge (HB) diode-clamped four-level LLC resonant converter based on multi-neighboring reference vector discontinuous pulse-width modulation (MNRV DPWM). While maintaining the ...
-
Article
Open AccessThe equilibrium of tumor suppression: DUBs as active regulators of PTEN
PTEN is among the most commonly lost or mutated tumor suppressor genes in human cancer. PTEN, a bona fide lipid phosphatase that antagonizes the highly oncogenic PI3K-AKT-mTOR pathway, is considered a major dose-...
-
Article
Neural Network-Based Adaptive Control Design of Dual-Spin Projectile with Rotating Canards
Guided munition is composed of a highly rotating main body and a guidance/control fuze with two pairs of control canards. The guidance/control fuze rotates in an opposite direction at a slower rate than the ma...
-
Article
Open AccessPTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression
PTEN is a lipid phosphatase that antagonizes the PI3K/AKT pathway and is recognized as a major dose-dependent tumor suppressor. The cellular mechanisms that control PTEN levels therefore offer potential routes...
-
Article
Open AccessLong-term PGC1β overexpression leads to apoptosis, autophagy and muscle wasting
Skeletal muscle wasting is prevalent in many chronic diseases, necessitating inquiries into molecular regulation of muscle mass. Nuclear receptor co-activator peroxisome proliferator-activated receptor co-acti...
-
Article
Open AccessExercise-like effects by Estrogen-related receptor-gamma in muscle do not prevent insulin resistance in db/db mice
Dissecting exercise-mimicking pathways that can replicate the benefits of exercise in obesity and diabetes may lead to promising treatments for metabolic disorders. Muscle estrogen-related receptor gamma (ERRγ...
-
Article
The functions and regulation of the PTEN tumour suppressor
PTEN (phosphatase and tensin homologue) is frequently disrupted in multiple sporadic tumours, and targeted by germline mutations in patients with cancer predis...
-
Article
The deubiquitinylation and localization of PTEN are regulated by a HAUSP–PML network
The exclusion of the tumour suppressor PTEN from the cell nucleus has been linked with tumour progression; the mechanisms behind its aberrant localization are obscure, although ubiquitinylation of specific lys...
-
Article
The tumour suppressor RASSF1A regulates mitosis by inhibiting the APC–Cdc20 complex
The tumour suppressor gene RASSF1A is frequently silenced in lung cancer and other sporadic tumours as a result of hypermethylation of a CpG island in its promoter1,2,3,4,5,6. However, the precise mechanism by wh...
