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Article
Open AccessMitochondrial SIRT3 as a protective factor against cyclosporine A-induced nephrotoxicity
Sirtuin3 (SIRT3), a mitochondrial deacetylase, has been shown to be involved in various kidney diseases. In this study, we aimed to clarify the role of SIRT3 in cyclosporine-induced nephrotoxicity and the asso...
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Article
Open AccessImpact of water consumption on renal function in the general population: a cross-sectional analysis of KNHANES data (2008–2017)
The renoprotective effect of water intake remains unclear. We aimed to investigate the relationship between water intake and renal impairment in the Korean general population, focusing on individual difference...
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Article
RUNX3 suppresses metastasis and stemness by inhibiting Hedgehog signaling in colorectal cancer
Disabled tumor suppressor genes and hyperactive oncogenes greatly contribute to cell fates during cancer development because of their genetic alterations such as somatic mutations. However, little is known abo...
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Article
Activating CCT2 triggers Gli-1 activation during hypoxic condition in colorectal cancer
Hypoxia, or the deficiency of oxygen, in solid tumors is majorly responsible for the progression of cancer and remains unaffected by chemotherapy, but still requires definitive definition of the hypoxia signal...
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Article
Open AccessCannabidiol promotes apoptosis via regulation of XIAP/Smac in gastric cancer
According to recent studies, Cannabidiol (CBD), one of the main components of Cannabis sativa, has anticancer effects in several cancers. However, the exact mechanism of CBD action is not currently understood. He...
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Article
Open AccessGenipin induces mitochondrial dysfunction and apoptosis via downregulation of Stat3/mcl-1 pathway in gastric cancer
Genipin is a compound derived from gardenia fruit extract. Although Genipin has anti-tumor effects in various cancers, its effect and mechanism in gastric cancer remain unclear. Here, we investigated the relat...
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Article
RUNX3 enhances TRAIL-induced apoptosis by upregulating DR5 in colorectal cancer
RUNX3 is frequently inactivated by DNA hypermethylation in numerous cancers. Here, we show that RUNX3 has an important role in modulating apoptosis in immediate response to tumor necrosis factor-related apopto...
