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Article
Open AccessAutomated cell-type classification combining dilated convolutional neural networks with label-free acoustic sensing
This study aimed to automatically classify live cells based on their cell type by analyzing the patterns of backscattered signals of cells with minimal effect on normal cell physiology and activity. Our previo...
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Article
Open AccessAdvanced trap lateral flow immunoassay sensor for the detection of cortisol in human bodily fluids
Paper-based biosensors based on lateral flow immunoassay (LFI) are promising candidates for POC diagnosis because of their ease of use and rapid target detection. However, the low sensitivity of LFI limits its...
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Chapter
Paper-Based Molecular Diagnostics
Nucleic acids have been widely recognized as ideal biomarkers in various applications, such as microorganism detection, [50] medical diagnostics [15, 24, 25], food safety [9, 54], environmental monitoring [73], a...
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Article
Open AccessInvestigation of cell mechanics using single-beam acoustic tweezers as a versatile tool for the diagnosis and treatment of highly invasive breast cancer cell lines: an in vitro study
Advancements in diagnostic systems for metastatic cancer over the last few decades have played a significant role in providing patients with effective treatment by evaluating the characteristics of cancer cell...
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Article
Advancements in DNA-assisted Immunosensors
Several types of biosensors have been developed to detect a wide variety of human diseases. Immunosensors are classified as the most representative of all biosensors. They are based on antibodies that selectiv...
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Article
Aptamer-based selective KB cell killing by the photothermal effect of gold nanorods
Development of both specific receptors against target cancer cells and therapeutic tools using receptor-functionalized nanoplatforms are important in cancer treatment. To address these challenges, we developed...
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Article
Design, Synthesis, and Evaluation of Gold Nanoparticle-Antibody-Horseradish Peroxidase Conjugates for Highly Sensitive Chemiluminescence Immunoassay (hs-CLIA)
Design and synthesis of a conjugate with high specificity and sensitivity constitutes a fundamental process for develo** a highly sensitive immunoassay. In this study, we investigated the process of design, ...
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Article
Open AccessLabel-free analysis of the characteristics of a single cell trapped by acoustic tweezers
Single-cell analysis is essential to understand the physical and functional characteristics of cells. The basic knowledge of these characteristics is important to elucidate the unique features of various cells...
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Article
Open AccessDirect and sustained intracellular delivery of exogenous molecules using acoustic-transfection with high frequency ultrasound
Controlling cell functions for research and therapeutic purposes may open new strategies for the treatment of many diseases. An efficient and safe introduction of membrane impermeable molecules into target cel...
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Article
Evaluation of the transfer rate of ochratoxin a to decoctions of herbal medicines
Ochratoxin A (OTA), a mycotoxin classified as a potentially carcinogenic to humans, is slightly soluble in water. In this study, the transfer rate of OTA in herbal medicines to decoctions was investigated. Her...
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Article
Colorimetric detection of PCR products of DNA from pathogenic bacterial targets based on a simultaneously amplified DNAzyme
A novel strategy was devised for colorimetric analysis of the products of the polymerase chain reaction (PCR). The method takes advantage of simultaneous amplification of a horseradish peroxidase-mimicking DNA...
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Article
Label-free measurement of cell viability via counting cells attached on affinity substrates
The commonly used trypan blue dye exclusion method and other modified cell viability methods, such as fluorescein dye and tetrazolium dye exclusion, artificially introduce toxic chemicals to cells and, thus, a...
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Article
Rapid colorimetric detection of Salmonella typhimuriumusing a selective filtration technique combined with antibody–magnetic nanoparticle nanocomposites
Detection of pathogenic bacteria that pose a great risk to human health requires a rapid, convenient, reliable, and sensitive detection method. In this study, we developed a selective filtration method using m...
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Article
Photoactivated immobilization of single-stranded DNAs on a psoralen-functionalized surface under low pH conditions
Single stranded DNA was photo-patterned on a psoralen-functionalized surface and conjugated with a psoralen-modified enzyme. Photoreactions between the single-stranded DNA and psoralen-functionalized materials...
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Chapter and Conference Paper
Loss-Free Slotted OBS for Ring and Mesh Hybrid Networks
This paper proposes a loss-free time-slot allocation (LTA) algorithm working on Optical Burst Switching (OBS) for ring and mesh hybrid networks. It preserves the number of time-slots for each source node, so t...
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Chapter and Conference Paper
A Data Profile-Based Contention-Free MAC Protocol for the Patient Monitoring Systems on WBANs
The patient monitoring system is one of the essential medical systems to help medical team monitoring the vital signs of patients for 24 hours and giving emergency treatment at the critical abnormal condition....
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Article
A CMOS image sensor to recognize the cardiovascular disease markers troponin I and C-reactive protein
A complementary metal oxide semiconductor (CMOS) image sensor was utilized to detect the interaction of cardiovascular disease markers, troponin I and C-reactive protein. Each marker with its respective antibo...
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Article
CMOS image sensor for detection of interferon gamma protein interaction as a point-of-care approach
Complementary metal oxide semiconductor (CMOS)-based image sensors have received increased attention owing to the possibility of incorporating them into portable diagnostic devices. The present research examin...
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Article
Detection of E. coli O157:H7 using its endogenous active membrane peroxidase
Recently, new virulent strain of Escherichia coli (E. coli) bacteria (0104:H4) was identified, causing ongoing outbreak of food poisoning in Europe, infecting up to 1,600 people with 18 deaths, especially in Germ...
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Article
Development of a surface plasmon resonance-based immunosensor for the rapid detection of cardiac troponin I
The concentration of cardiac troponin I (cTnI) in blood is an important marker for heart muscle cell damage. A surface plasmon resonance (SPR)-based immunosensor was devised for the rapid and specific detectio...
