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Article
Open AccessComputer-aided design and 3D printing for a stable construction of segmental bone defect model in Beagles: a short term observation
Segmental bone defect animal studies require stable fixation which is a continuous experimental challenge. Large animal models are comparable to the human bone, but with obvious drawbacks of housing and costs....
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Article
Open AccessMetabolomics combined with network pharmacology reveals a role for astragaloside IV in inhibiting enterovirus 71 replication via PI3K-AKT signaling
Astragaloside IV (AST-IV), as an effective active ingredient of Astragalus membranaceus (Fisch.) Bunge. It has been found that AST-IV inhibits the replication of dengue virus, hepatitis B virus, adenovirus, an...
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Article
Open AccessAmplification, Resistance, and Kinetics of the Jaw Stretching Device (ARK-JSD): analysis of the force variation and implications for trismus therapy
Jaw-stretching devices, including the Amplification, Resistance, and Kinetics of the Jaw (ARK-JSD), are an effective option for treating trismus after head and neck cancer (HNC) treatment. The force, however, ...
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Article
Sex differences in the management of patients with suspected acute coronary syndrome in China
Few studies have assessed sex differences in the management of suspected acute coronary syndrome (ACS). We aimed to compare the evaluation, treatment, and outcomes between males and females with suspected ACS ...
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Article
Aβ1−42 stimulates an increase in autophagic activity through tunicamycin-induced endoplasmic reticulum stress in HTR-8/SVneo cells and late-onset pre-eclampsia
Environmental changes can trigger endoplasmic reticulum (ER) stress and misfolded protein accumulation, potentially leading to pre-eclampsia (PE). Amyloid-β (Aβ) is a crucial misfolded protein that can overact...
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Article
Open AccessCarbon storage through China’s planted forest expansion
China’s extensive planted forests play a crucial role in carbon storage, vital for climate change mitigation. However, the complex spatiotemporal dynamics of China’s planted forest area and its carbon storage ...
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Article
Conserving the primary forests in the Yarlung Tsangpo Grand Canyon for people and nature
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Article
Detoxification strategy of Microcystis aeruginosa to the toxicity of Cd(II): role of EPS in alleviating toxicity
Although many studies have found that cadmium (Cd) can be toxic to microalgae, only a few reports focused on the role of extracellular polymeric substances (EPS) in Cd(II) detoxification. The biochemical and p...
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Article
Utilizing interpretable stacking ensemble learning and NSGA-III for the prediction and optimisation of building photo-thermal environment and energy consumption
This study develops an approach consisting of a stacking model integrated with a multi-objective optimisation algorithm aimed at predicting and optimising the ecological performance of buildings. The integrate...
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Article
Jellyfish bio-inspired Fe@CNT@CuNC derived from ZIF-8 for cathodic oxygen reduction
Biomimetics provides guidance to design and synthesize advanced catalysts for oxygen reduction reaction in microbial fuel cells (MFCs). Herein, jellyfish-inspired Fe clusters on carbon nanotubes connected with...
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Article
Early, non-invasive detection of radiation-induced lung injury using PET/CT by targeting CXCR4
Radiation-induced lung injury (RILI) is a severe side effect of radiotherapy (RT) for thoracic malignancies and we currently lack established methods for the early detection of RILI. In this study, we synthesi...
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Article
Open AccessPilot Study of Intensive Trismus Intervention Using Restorabite™ During Unilateral Adjuvant Radiation for Head and Neck Cancer
Trismus commonly arises after surgery for head and neck cancer (HNC) and its severity is potentiated by postoperative radiotherapy. While the benefit of trismus rehabilitation after surgery and radiotherapy is...
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Article
Instantaneous inversion of transient electromagnetic data using machine learning
Inverse problems are typically tackled using deterministic optimization methods that may become trapped in a local minimum or probabilistic methods that can be computationally demanding. In this study, we expl...
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Article
Increased 18F-FAPI uptake in bones and joints of lung cancer patients: characteristics and distributions
This study investigated the distribution and characteristics of various bone and joint lesions on 18F-FAPI PET/CT in lung cancer patients.
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Article
Open AccessIncreasing serum miR-409-3p predicts the major adverse cardiac adverse events in elderly patients after hip fracture surgery
Major adverse cardiovascular events (MACE) are critical complications responsible for the morbidity and mortality of elderly hip fracture patients. There was an urgent need to explore an effect biomarker for p...
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Article
Open AccessWafer-scale organic-on-III-V monolithic heterogeneous integration for active-matrix micro-LED displays
The organic thin-film transistor is advantageous for monolithic three-dimensional integration attributed to low temperature and facile solution processing. However, the electrical properties of solution deposi...
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Article
Precipitation effect on Surface roughness at Ti-6Al-4 V ELI alloy during Ultra-Precision Machining
Ti6Al4V ELI (Extra-low interstitial) alloy is quite popular due to its application in the fields of biomedical, aerospace, optics and aeronautic industry, because of its high-strength to weight ratio, anti-cor...
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Article
Open AccessStudy on pum** wear characteristics of concrete pipeline based on CFD-DEM coupling
Concrete pum**, integral to building construction, governs pipeline durability and overall construction efficiency. This study advances the traditional methods by employing the CFD-DEM coupling technique, a ...
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Article
[18F] AlF-NOTA-FAPI-04 PET/CT can predict treatment response and survival in patients receiving chemotherapy for inoperable pancreatic ductal adenocarcinoma
We investigated whether uptake of [18F] AlF-NOTA-FAPI-04 on positron emission tomography/computed tomography (PET/CT) could predict treatment response and survival in patients with pancreatic ductal adenocarcinom...
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Article
Evaluation of 18F-FAPI-04 Imaging in Assessing the Therapeutic Response of Rheumatoid Arthritis
Fibroblast activating protein (FAP) is highly expressed in the synovial tissues of rheumatoid arthritis (RA) patients. The aim of this study was to determine the feasibility of PET imaging with an Al[18F] F-NOTA-...
