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Article
Open AccessThe prion protein family member Shadoo induces spontaneous ionic currents in cultured cells
Some mutant forms of the cellular prion protein (PrPC) carrying artificial deletions or point mutations associated with familial human prion diseases are capable of inducing spontaneous ionic currents across the ...
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Article
Open AccessA cationic tetrapyrrole inhibits toxic activities of the cellular prion protein
Prion diseases are rare neurodegenerative conditions associated with the conformational conversion of the cellular prion protein (PrPC) into PrPSc, a self-replicating isoform (prion) that accumulates in the centr...
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Article
SK channel modulation rescues striatal plasticity and control over habit in cannabinoid tolerance
In a mouse model of cannabinoid tolerance, persistent activation of the eCB pathway impairs eCB-mediated long-term depression (LTD) preferentially at connections to striatopallidal neurons. This is associated ...