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Article
Open AccessRole of interleukin-6 and interleukin-10 in morphological and functional changes of the blood–brain barrier in hypertriglyceridemia
Hypertriglyceridemia is closely linked to atherosclerosis related inflammatory processes and blood–brain barrier (BBB) dysfunction. Using apolipoprotein B-100 (APOB-100) transgenic mice, an animal model of chr...
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Article
Quantum generalizations of the polynomial hierarchy with applications to QMA(2)
The polynomial-time hierarchy (PH) has proven to be a powerful tool for providing separations in computational complexity theory (modulo standard conjectures such as PH do not collapse). Here, we study whether...
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Article
Open AccessExercise training worsens cardiac performance in males but does not change ejection fraction and improves hypertrophy in females in a mouse model of metabolic syndrome
Metabolic syndrome (MetS) refers to a cluster of co-existing cardio-metabolic risk factors, including visceral obesity, dyslipidemia, hyperglycemia with insulin resistance, and hypertension. As there is a clos...
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Article
Characterising the intersection of QMA and coQMA
We show that the functional analogue of \(\textsc {QMA} \cap \textsc {coQMA} \) QMA ...
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Article
Total functions in QMA
The complexity class \({\textsc {QMA}}\) QMA is the quantum analog of the c...
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Article
Open AccessNeuroinflammatory processes are augmented in mice overexpressing human heat-shock protein B1 following ethanol-induced brain injury
Heat-shock protein B1 (HSPB1) is among the most well-known and versatile member of the evolutionarily conserved family of small heat-shock proteins. It has been implicated to serve a neuroprotective role again...
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Article
Open AccessBiologia futura: animal testing in drug development—the past, the present and the future
Animal experiments have served to improve our knowledge on diseases and treatment approaches since ancient times. Today, animal experiments are widely used in medical, biomedical and veterinary research, and a...
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Article
Open AccessSynaptic mitochondrial dysfunction and septin accumulation are linked to complement-mediated synapse loss in an Alzheimer’s disease animal model
Synaptic functional disturbances with concomitant synapse loss represent central pathological hallmarks of Alzheimer’s disease. Excessive accumulation of cytotoxic amyloid oligomers is widely recognized as a k...
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Article
Quadratically Tight Relations for Randomized Query Complexity
In this work we investigate the problem of quadratically tightly approximating the randomized query complexity of Boolean functions R(f). The certificate complexity C(f) is such a complexity measure for the zero-...
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Article
Polynomial Interpolation and Identity Testing from High Powers Over Finite Fields
We consider the problem of recovering (that is, interpolating) and identity testing of a “hidden” monic polynomial f, given an oracle access to ...
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Chapter and Conference Paper
Quadratically Tight Relations for Randomized Query Complexity
In this work we investigate the problem of quadratically tightly approximating the randomized query complexity of Boolean functions $$...
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Chapter and Conference Paper
A New Public-Key Cryptosystem via Mersenne Numbers
In this work, we propose a new public-key cryptosystem whose security is based on the computational intractability of the following problem: Given a Mersenne number
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Article
Open AccessAbstracts from the 20th International Symposium on Signal Transduction at the Blood-Brain Barriers
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Article
Improved Quantum Query Algorithms for Triangle Detection and Associativity Testing
We show that the quantum query complexity of detecting if an n-vertex graph contains a triangle is \(O(n^{9/7})\) ...
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Article
Open AccessCultured cells of the blood–brain barrier from apolipoprotein B-100 transgenic mice: effects of oxidized low-density lipoprotein treatment
The apolipoprotein B-100 (ApoB-100) transgenic mouse line is a model of human atherosclerosis. Latest findings suggest the importance of ApoB-100 in the development of neurodegenerative diseases and microvascu...
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Chapter and Conference Paper
Quantum and Randomized Query Complexities (Extended Abstract)
Deterministic query complexity is a simplified model of computation where the resource measured is only the number of questions to the input to get information about individual input bits, while all other oper...
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Chapter
How to Stabilize Both the Proteins and the Membranes: Diverse Effects of sHsps in Neuroprotection
Small heat shock proteins (sHsps) are ubiquitously expressed evolutionarily conserved proteins which are upregulated by different stressors and in various pathological conditions in the brain. The most importa...
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Chapter and Conference Paper
On Solving Systems of Diagonal Polynomial Equations Over Finite Fields
We present a randomized algorithm to solve a system of diagonal polynomial equations over finite fields when the number of variables is greater than some fixed polynomial of the number of equations whose degre...
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Article
Alcohol stress, membranes, and chaperones
Ethanol, which affects all body organs, exerts a number of cytotoxic effects, most of them independent of cell type. Ethanol treatment leads to increased membrane fluidity and to changes in membrane protein co...
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Chapter and Conference Paper
An Efficient Quantum Algorithm for Finding Hidden Parabolic Subgroups in the General Linear Group
In the theory of algebraic groups, parabolic subgroups form a crucial building block in the structural studies. In the case of general linear groups over a finite field
