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Article
Open AccessCyclical dermal micro-niche switching governs the morphological infradian rhythm of mouse zigzag hair
Biological rhythms are involved in almost all types of biological processes, not only physiological processes but also morphogenesis. Currently, how periodic morphological patterns of tissues/organs in multice...
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Article
Author Correction: Human induced pluripotent stem cell-derived salivary gland organoids model SARS-CoV-2 infection and replication
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Article
Human induced pluripotent stem cell-derived salivary gland organoids model SARS-CoV-2 infection and replication
Salivary glands act as virus reservoirs in various infectious diseases and have been reported to be targeted by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the mechanisms underlying ...
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Article
Open AccessExpansion and characterization of epithelial stem cells with potential for cyclical hair regeneration
In mammals, organ induction occurs only during embryonic development except for hair follicles (HFs). However, HF-resident epithelial stem cells (HFSCs), which are responsible for repetitive HF regeneration, a...
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Article
Open AccessTissue-scale tensional homeostasis in skin regulates structure and physiological function
Tensional homeostasis is crucial for organ and tissue development, including the establishment of morphological and functional properties. Skin plays essential roles in waterproofing, cushioning and protecting...
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Article
Open AccessEmergence of carbapenem-resistant and colistin-susceptible Enterobacter cloacae complex co-harboring blaIMP-1 and mcr-9 in Japan
The spread of Enterobacteriaceae producing both carbapenemases and Mcr, encoded by plasmid-mediated colistin resistance genes, has become a serious public health problem worldwide. This study describes three clin...
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Article
Open AccessVisualization of junctional epithelial cell replacement by oral gingival epithelial cells over a life time and after gingivectomy
Junctional epithelium (JE), which is derived from odontogenic epithelial cells immediately after eruption, is believed to be gradually replaced by oral gingival epithelium (OGE) over a lifetime. However, the d...
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Article
Regeneration of a bioengineered 3D integumentary organ system from iPS cells
Organ systems play essential roles in the physiological functions required for homeostasis. A 3D integumentary organ system (3D-IOS) comprises the skin and skin appendages such as hair follicles and sebaceous ...
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Article
Chronic inflammatory demyelinating polyneuropathy in adult T-cell leukemia-lymphoma patients following allogeneic stem cell transplantation
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Article
Open AccessGeneration of orthotopically functional salivary gland from embryonic stem cells
Organoids generated from pluripotent stem cells are used in the development of organ replacement regenerative therapy by recapitulating the process of organogenesis. These processes are strictly regulated by m...
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Article
Circulating tumor DNA dynamically predicts response and/or relapse in patients with hematological malignancies
A growing body of evidence suggests that tumor-derived fragmentary DNA, known as circulating tumor DNA (ctDNA), has the potential to serve as a non-invasive biomarker for disease monitoring. However, in the se...
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Article
Open AccessPractical whole-tooth restoration utilizing autologous bioengineered tooth germ transplantation in a postnatal canine model
Whole-organ regeneration has great potential for the replacement of dysfunctional organs through the reconstruction of a fully functional bioengineered organ using three-dimensional cell manipulation in vitro. Re...
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Article
Functional Salivary Gland Regenerative Therapy for Oral Health
Salivary glands maintain oral health and homeostasis via functional interactions with many organs, including the teeth and the tongue. Dysfunction of salivary glands causes many problems, such as dental caries...
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Protocol
Functional Salivary Gland Regeneration
The salivary gland plays important roles in maintaining the health and homeostasis of the oral cavity by regulating functions, such as chewing, digestion, cleaning, and swallowing. Salivary gland dysfunction c...
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Functional Salivary Gland Regeneration
Oral health and homeostasis are maintained by the functional interactions of many organs, including the salivary glands, teeth, and tongue. Salivary gland dysfunction leads to dry mouth diseases, such as denta...
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Protocol
Functional Tooth Regeneration
Three-dimensional organogenesis in vivo is principally regulated by the spatiotemporal developmental process that relies on the cellular behavior such as cell growth, migration, differentiation, and cell-to-ce...
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Article
Open AccessFunctional tooth restoration utilising split germs through re-regionalisation of the tooth-forming field
The tooth is an ectodermal organ that arises from a tooth germ under the regulation of reciprocal epithelial-mesenchymal interactions. Tooth morphogenesis occurs in the tooth-forming field as a result of react...
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Article
Functional salivary gland regeneration as the next generation of organ replacement regenerative therapy
Oral health is maintained by the coordinated function of many organs including the teeth and salivary glands. Dysfunction of these organs causes many problems, such as dental caries, swallowing dysfunction an...
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Article
Open AccessFunctional tooth restoration by next-generation bio-hybrid implant as a bio-hybrid artificial organ replacement therapy
Bio-hybrid artificial organs are an attractive concept to restore organ function through precise biological cooperation with surrounding tissues in vivo. However, in bio-hybrid artificial organs, an artificial or...
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Article
Open AccessThe junctional epithelium originates from the odontogenic epithelium of an erupted tooth
The junctional epithelium (JE) is an epithelial component that is directly attached to the tooth surface and has a protective function against periodontal diseases. In this study, we determined the origin of t...
