6 Result(s)
within
Michiko Ichii
Oncology
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Article
High numbers of programmed cell death-1-positive tumor infiltrating lymphocytes correlate with early onset of post-transplant lymphoproliferative disorder
Post-transplant lymphoproliferative disorder (PTLD) is a life-threatening complication of transplantation. In addition to reactivation of Epstein–Barr virus in immunocompromised patients, impaired tumor immuni...
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Article
Open AccessEctonucleotidase CD39 is highly expressed on ATLL cells and is responsible for their immunosuppressive function
Adult T-cell leukemia/lymphoma (ATLL) patients have an extremely poor prognosis, partly due to their immunosuppressive state. The majority of ATLL patients have leukemic cells with phenotype similar to Tregs, ...
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Article
Open AccessSignal-transducing adapter protein-1 is required for maintenance of leukemic stem cells in CML
The family of signal-transducing adapter proteins (STAPs) has been reported to be involved in a variety of intracellular signaling pathways and implicated as transcriptional factors. We previously cloned STAP-...
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Article
Noninvasive assessment of corneal alterations associated with monoclonal gammopathy
Aggregation of monoclonal immunoglobulin can lead to organ damage. However, the necessity of invasive examination such as biopsy has hampered better understanding of the pathophysiology. Corneal crystalline de...
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Article
Prominent regression of corneal crystalline deposits in multiple myeloma after treatment with proteasome inhibitor
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Article
Complementary regulation of early B-lymphoid differentiation by genetic and epigenetic mechanisms
Although B lymphopoiesis is one of the best-defined paradigms in cell differentiation, our knowledge of the regulatory mechanisms underlying its earliest processes, in which hematopoietic stem cells (HSCs) en...
