7 Result(s)
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Michelle S. M. A. Damen
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Article
Open AccessNon-hematopoietic IL-4Rα expression contributes to fructose-driven obesity and metabolic sequelae
The risks of excess sugar intake in addition to high-fat diet consumption on immunopathogenesis of obesity-associated metabolic diseases are poorly defined. Interleukin-4 (IL-4) and IL-13 signaling via IL-4Rα ...
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Open AccessAging mitigates the severity of obesity-associated metabolic sequelae in a gender independent manner
Understanding gender-associated bias in aging and obesity-driven metabolic derangements has been hindered by the inability to model severe obesity in female mice.
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Article
Open AccessA BAFF/APRIL axis regulates obesogenic diet-driven weight gain
The impact of immune mediators on weight homeostasis remains underdefined. Interrogation of resistance to diet-induced obesity in mice lacking a negative regulator of Toll-like receptor signaling serendipitous...
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Open AccessType I interferon sensing unlocks dormant adipocyte inflammatory potential
White adipose tissue inflammation, in part via myeloid cell contribution, is central to obesity pathogenesis. Mechanisms regulating adipocyte inflammatory potential and consequent impact of such inflammation i...
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Open AccessGenetic variant in IL-32 is associated with the ex vivo cytokine production of anti-TNF treated PBMCs from rheumatoid arthritis patients
About 60% of RA patients don’t achieve good response with biological disease-modifying anti-rheumatic drugs bDMARD treatment (including TNF inhibitors, TNFi’s). Previously, a link between TNFα and interleukin ...
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Open AccessThe NOD2 receptor is crucial for immune responses towards New World Leishmania species
American Tegumentary Leishmaniasis is a chronic infection caused by Leishmania protozoan. It is not known whether genetic variances in NOD-like receptor (NLR) family members influence the immune response towards
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Article
Open AccessIL-32 promoter SNP rs4786370 predisposes to modified lipoprotein profiles in patients with rheumatoid arthritis
Patients with rheumatoid arthritis (RA) are at higher risk of develo** cardiovascular diseases (CVD). Interleukin (IL)-32 has previously been shown to be involved in the pathogenesis of RA and might be linke...
