10 Result(s)
within
Maria E. Moreno-Fernandez
-
Article
Open AccessNon-hematopoietic IL-4Rα expression contributes to fructose-driven obesity and metabolic sequelae
The risks of excess sugar intake in addition to high-fat diet consumption on immunopathogenesis of obesity-associated metabolic diseases are poorly defined. Interleukin-4 (IL-4) and IL-13 signaling via IL-4Rα ...
-
Article
Open AccessAging mitigates the severity of obesity-associated metabolic sequelae in a gender independent manner
Understanding gender-associated bias in aging and obesity-driven metabolic derangements has been hindered by the inability to model severe obesity in female mice.
-
Article
Open AccessA BAFF/APRIL axis regulates obesogenic diet-driven weight gain
The impact of immune mediators on weight homeostasis remains underdefined. Interrogation of resistance to diet-induced obesity in mice lacking a negative regulator of Toll-like receptor signaling serendipitous...
-
Article
Open AccessType I interferon sensing unlocks dormant adipocyte inflammatory potential
White adipose tissue inflammation, in part via myeloid cell contribution, is central to obesity pathogenesis. Mechanisms regulating adipocyte inflammatory potential and consequent impact of such inflammation i...
-
Reference Work Entry In depth
Role of Regulatory T Cells During HIV Infection
-
Article
Erratum: Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling
Nat. Med.; 10.1038/nm.4346; corrected online 21 June 2017 In the version of this article initially published online, a grant supporting the authors' work was omitted from the Acknowledgments section. The grant...
-
Article
Thermoneutral housing exacerbates nonalcoholic fatty liver disease in mice and allows for sex-independent disease modeling
Current mouse models of nonalcoholic steatohepatitis are limited, making identification and preclinical testing of new treatments challenging. Housing mice at thermoneutrality leads to less stress, a stronger ...
-
Article
Open AccessIL-1β induced HIF-1α inhibits the differentiation of human FOXP3+ T cells
Differentiation of regulatory Treg (Treg) in the periphery is critical to control inflammatory processes. Although polarization of inducible Treg (iTreg) often occurs in an inflammatory environment, the effect...
-
Living Reference Work Entry In depth
Role of Regulatory T Cells During HIV Infection
-
Article
Open AccessLow-level HIV infection of hepatocytes
There are only limited data on whether HIV infection occurs within the liver; therefore, we explored early and late stages of the HIV life cycle in two hepatocyte cell lines – Huh7.5 and Huh7.5JFH1 – as well as i...
