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Article
Exploring mitochondrial heteroplasmy in neonates: implications for growth patterns and overweight in the first years of life
Mitochondrial heteroplasmy reflects genetic diversity within individuals due to the presence of varying mitochondrial DNA (mtDNA) sequences, possibly affecting mitochondrial function and energy production in c...
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Article
Open AccessMaternal educational attainment in pregnancy and epigenome-wide DNA methylation changes in the offspring from birth until adolescence
Maternal educational attainment (MEA) shapes offspring health through multiple potential pathways. Differential DNA methylation may provide a mechanistic understanding of these long-term associations. We aimed...
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Article
Open AccessCord blood epigenome-wide meta-analysis in six European-based child cohorts identifies signatures linked to rapid weight growth
Rapid postnatal growth may result from exposure in utero or early life to adverse conditions and has been associated with diseases later in life and, in particular, with childhood obesity. DNA methylation, interf...
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Article
Open AccessCord blood metabolites and rapid postnatal growth as multiple mediators in the prenatal propensity to childhood overweight
The mechanisms underlying childhood overweight and obesity are poorly known. Here, we investigated the direct and indirect effects of different prenatal exposures on offspring rapid postnatal growth and overwe...
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Article
Open AccessCord blood metabolic signatures predictive of childhood overweight and rapid growth
Metabolomics may identify biological pathways predisposing children to the risk of overweight and obesity. In this study, we have investigated the cord blood metabolic signatures of rapid growth in infancy and...
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Article
Open AccessLower iodine storage in the placenta is associated with gestational diabetes mellitus
The micronutrient iodine is essential for a healthy intrauterine environment and is required for optimal fetal growth and neurodevelopment. Evidence linking urinary iodine concentrations, which mainly reflects...
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Article
Open AccessChildren’s microvascular traits and ambient air pollution exposure during pregnancy and early childhood: prospective evidence to elucidate the developmental origin of particle-induced disease
Particulate matter exposure during in utero life may entail adverse health outcomes later in life. The microvasculature undergoes extensive, organ-specific prenatal maturation. A growing body of evidence shows th...
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Article
Open AccessTelomere tracking from birth to adulthood and residential traffic exposure
Telomere attrition is extremely rapid during the first years of life, while lifestyle during adulthood exerts a minor impact. This suggests that early life is an important period in the determination of telome...
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Article
Open AccessMaternal pre-pregnancy body mass index and newborn telomere length
Newborn telomere length sets telomere length for later life. At birth, telomere length is highly variable among newborns and the environmental factors during in utero life for this observation remain largely unid...
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Article
Open AccessAltered neonatal cord blood oxylipidome in association with exposure to particulate matter in the early life environment