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Article
Fluorogenic reporter enables identification of compounds that inhibit SARS-CoV-2
The coronavirus SARS-CoV-2 causes the severe disease COVID-19. SARS-CoV-2 infection is initiated by interaction of the viral spike protein and host receptor angiotensin-converting enzyme 2 (ACE2). We report an...
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Chapter
RNA Interference-Mediated Intrinsic Antiviral Immunity in Invertebrates
In invertebrates such as insects and nematodes, RNA interference (RNAi) provides RNA-based protection against viruses. This form of immunity restricts viral replication and dissemination from infected cells an...
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Article
Cricket paralysis virus antagonizes Argonaute 2 to modulate antiviral defense in Drosophila
Some viruses carry suppressors to inhibit host response to infection through the RNAi pathways. Previously the insect virus DCV was found to target host response by inhibiting Drosophila Dicer function. The relat...
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Article
Antiviral immunity in Drosophila requires systemic RNA interference spread
Drosophila and other insects are known to be able to mount a local antiviral defence involving RNA interference (RNAi). It was previously thought that Drosophila is unable to systemically spread an RNAi response,...
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Article
Transcriptional control of dendritic patterning in Drosophila neurons
How the morphology of individual neurons is controlled remains poorly understood. A recent in vivo genome-wide screen based on RNA interference identified a large number of transcriptional factors that regulate t...
