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Open AccessPlasma ALS and Gal-3BP differentiate early from advanced liver fibrosis in MASLD patients
Metabolic dysfunction-associated steatotic liver disease (MASLD) is estimated to affect 30% of the world’s population, and its prevalence is increasing in line with obesity. Liver fibrosis is closely related t...
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Mass Spectrometry-Based Proteomics Analyses of Integral Membrane Proteins
The present work compares two proteomics approaches for the analysis of integral membrane proteins (IMPs). Membrane proteins from human U937 monocytes were enriched in IMP following alkaline solvent extraction...
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Structural and functional characterization of 2-oxo-histidine in oxidized PerR protein
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Characterization by Mass Spectroscopy of a 10 kDa c-554 Cytochrome from the Green Sulfur Bacterium Chlorobium tepidum
Preparative isoelectric focusing was used to isolate a type c cytochrome from photosynthetic membranes of the green sulfur bacterium Chlorobium tepidum. The purified protein showed a molecular weight of 10 kDa ac...
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Article
BRCA1 interacts with acetyl-CoA carboxylase through its tandem of BRCT domains
Germ-line alterations in BRCA1 are associated with an increased susceptibility to breast and ovarian cancer. BRCA1 is a 220-kDa protein that contains a tandem of two BRCA1 C-Terminal (BRCT) domains. Among missens...
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Probing the Influence of Mutations on the Stability of a Ferredoxin by Mass Spectrometry
Hydrogen/deuterium exchange, which depends on solvent accessibility, can be probed by mass spectrometry (MS) to get information on protein conformation or protein–ligand interaction. In this work, the conforma...