-
Article
Open AccessHeat-Induced Secretion of Heat Shock Proteins 70 and 90 Does not Affect the Expression of the Glucocorticoid Receptor in Primary Airway Cells in COPD
The response to glucocorticoids is hampered in many COPD patients by a yet unknown mechanism. Earlier we reported that short-term heat exposure of primary human bronchial epithelial cells (BEC) and airway smoo...
-
Article
A systematic review and meta-analysis of e-cigarette use among cancer survivors
We conducted a systematic review and meta-analysis to determine the use of e-cigarettes among cancer survivors, factors associated with their use, and prevalence of e-cigarette use as a quit attempt.
-
Article
Open AccessExpression of glucocorticoid receptor and HDACs in airway smooth muscle cells is associated with response to steroids in COPD
Steroid insensitivity in Chronic Obstructive Pulmonary Disease (COPD) presents a problem for controlling the chronic inflammation of the airways. The glucocorticoid receptor (GR) mediates the intracellular sig...
-
Article
Obesity Predisposes Anthracycline-Treated Survivors of Childhood and Adolescent Cancers to Subclinical Cardiac Dysfunction
Anthracyclines are effective chemotherapeutics used in approximately 60% of pediatric cancer cases but have a well-documented risk of cardiotoxicity. Existing cardiotoxicity risk calculators do not include car...
-
Chapter and Conference Paper
Rail Surface Defect Detection and Severity Analysis Using CNNs on Camera and Axle Box Acceleration Data
Rail surface defect detection is a relevant problem in the field of data-driven railway maintenance. Artificial intelligence and neural networks (NN) for axle box acceleration (ABA) or camera data show great p...
-
Article
Open AccessBlastic plasmacytoid dendritic cell neoplasm: a comprehensive review in pediatrics, adolescents, and young adults (AYA) and an update of novel therapies
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic malignancy that can involve the bone marrow, peripheral blood, skin, lymph nodes, and the central nervous system. Though more common i...
-
Article
Open AccessSymptom management care pathway adaptation process and specific adaptation decisions
There is substantial heterogeneity in symptom management provided to pediatric patients with cancer. The primary objective was to describe the adaptation process and specific adaptation decisions related to sy...
-
Article
Health-related quality of life in adolescents and young adults with cancer who received radiation therapy: a sco** review
Radiation therapy (RT) is a critical component of treatment for adolescents and young adults (AYAs, age 15–39 years old) diagnosed with cancer. Limited prior studies have focused on AYAs receiving RT despite t...
-
Article
Sex differences in comorbid conditions, health behaviors, health care utilization, and health-related quality of life among young adult cancer survivors
Although cancer experiences and health-related quality of life (HRQOL) differ by sex, little is known about how sex affects comorbid conditions, health behaviors, health service utilization, and HRQOL in young...
-
Article
Factors impacting adolescent and young adult cancer patients’ decision to pursue genetic counseling and testing
Adolescent and young adult (AYA) cancer patients face challenges when navigating cancer treatment and survivorship. Many are at risk for cancer predisposition syndromes; however, factors influencing pursuit of...
-
Article
Open AccessShared barriers and facilitators to enrollment of adolescents and young adults on cancer clinical trials
Adolescent and young adult (AYA) enrollment in cancer clinical trials (CCT) is suboptimal. Few studies have explored site level barriers and facilitators to AYA enrollment on CCTs and the efficacy of intervent...
-
Article
Open AccessBronchial thermoplasty in asthma: an exploratory histopathological evaluation in distinct asthma endotypes/phenotypes
Bronchial thermoplasty regulates structural abnormalities involved in airway narrowing in asthma. In the present study we aimed to investigate the effect of bronchial thermoplasty on histopathological bronchia...
-
Article
Open AccessSimultaneous learning of individual microRNA-gene interactions and regulatory comodules
MicroRNAs (miRNAs) function in post-transcriptional regulation of gene expression by binding to target messenger RNAs (mRNAs). Because of the key part that miRNAs play, understanding the correct regulatory rol...
-
Chapter
Ein Schritt zurück, zwei nach vorne Wie die Coronakrise uns lehrte, mit Mut die grenzüberschreitende Zusammenarbeit voranzubringen
L’histoire nous enseigne que l’intégration européenne ne progresse pas de manière linéaire mais par bonds, par sauts intégrateurs, bien souvent en réaction à une période de crise qui a mis à jour des lacunes. ...
-
Chapter
Bundesweite empirie- und modellgestützte Bewertung von Vielfalt, Eigenart und Schönheit des Landschaftsbildes
Derzeit fehlt es an Daten zur Bewertung von Eingriffen in das Landschaftsbild durch den Ausbau des Stromnetzes in Deutschland, die auf einer homogenen Methodik und einheitlichen Datengrundlage basieren und all...
-
Article
Meal planning values impacted by the cancer experience in families with school-aged survivors—a qualitative exploration and recommendations for intervention development
Increased cardiovascular disease and second cancer risks among childhood cancer survivors (CCS) makes them and their families important audiences for nutrition intervention. Family meals and home cooking pract...
-
Article
Microseismic events on the Åknes rockslide in Norway located by a back-projection approach
The Åknes rockslide in Western Norway is characterised by a steady movement of a rock mass with an extent of about 1 km2 and a yearly deformation rate in the range of 2 to 4 cm. A seismic network consisting of 8 ...
-
Chapter
Der Vertrag von Aachen – ein deutsch-französischer Anstoß für Europa
Seit über tausend Jahren ist die Stadt Aachen einer der großen Orte der europäischen Geschichte und Heimat des Mannes, der den Beinamen Pater Europae (Vater Europas) trägt. Hier zeugt bis heute die Lieblingspfalz...
-
Chapter
HER2-Targeted Therapy in Osteosarcoma
In this chapter, we will review studies of HER2 in osteosarcoma and discuss the controversies that have existed in this field. Our present understanding of HER2 in the context of osteosarcoma is that it is exp...
-
Chapter
Water Meadows as European Agricultural Heritage
From the Middle Ages until the twentieth century, water meadows in Europe were primarily irrigated to improve their productivity and to lengthen the growing season. They were water management systems designed ...
