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Article
Open AccessCOVID-19 among heart transplant recipients in Germany: a multicenter survey
Heart transplantation may represent a particular risk factor for severe coronavirus infectious disease 2019 (COVID-19) due to chronic immunosuppression and frequent comorbidities. We conducted a nation-wide su...
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Article
A novel risk score to predict survival in advanced heart failure due to cardiac amyloidosis
Cardiac amyloidosis, caused by deposition of immunoglobulin light chains (AL) or transthyretin (ATTR), carries a poor prognosis. Established risk scores for amyloidosis may not predict outcomes in those patien...
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Article
Open AccessBenefits of peritoneal ultrafiltration in HFpEF and HFrEF patients
Peritoneal ultrafiltration (pUF) in refractory heart failure (HF) reduces the incidence of decompensation episodes, which is of particular significance as each episode incrementally adds to mortality. Neverthe...
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Article
Implementation of an intensified outpatient follow-up protocol improves outcomes in patients with ventricular assist devices
Ventricular assist devices (VAD) are increasingly used as long-term treatment for advanced heart failure. However, survival after VAD implantation is still unsatisfactory, and no specific outpatient follow-up ...
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Article
Invasive hemodynamics and cardiac biomarkers to predict outcomes after percutaneous edge-to-edge mitral valve repair in patients with severe heart failure
Percutaneous mitral valve repair (PMVR) via MitraClip implantation is a therapeutic option for high-risk or non-surgical candidates with severe mitral regurgitation (MR) and advanced stages of heart failure (H...
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Inpatient Therapeutic Options
Patients with acute dyspnea resulting from acute heart failure should be rapidly assessed and stabilized. First, patients should be put in a seated posture and, if necessary, supplemental oxygen and ventilator...
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Article
A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway
A proteolytically derived fragment of the epigenetic regulator HDAC4 protects the heart through transcriptional repression of the hexosamine biosynthetic pathway, thereby inhibiting protein O-GlcNAcylation and...
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Article
Inducible cardiomyocyte-specific deletion of CaM kinase II protects from pressure overload-induced heart failure
CaM kinase II (CaMKII) has been suggested to drive pathological cardiac remodeling and heart failure. However, the evidence provided so far is based on inhibitory strategies using chemical compounds and peptid...