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Article
Different effects of chronic nicotine treatment regimens on body weight and tolerance in the rat
The effect of different chronic nicotine administration regimens on body weight and the development of tolerance was examined in female rats. Groups of animals were either treated with nicotine via a subcutane...
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Chapter
Differences in Antinociception Evoked from Dorsal and Ventral Regions of the Caudal Periaqueductal Gray Matter
Stimulation-produced antinociception (SPA) from the periaqueductal gray matter (PAG) was first reported by Reynolds in 1969. Mayer and co-workers (1971) further characterized this phenomenon, demonstrating tha...
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Article
Factors That Influence Willingness to Help the Homeless
Homelessness is an ongoing challenge for many families and individuals. Many struggle to meet their basic needs for food, clothing and shelter. Unfortunately, we know very little about the people...
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Article
Behavioral and Electrophysiological Evidence for Opioid Tolerance in Adolescent Rats
Morphine and other opiates are successful treatments for pain, but their usefulness is limited by the development of tolerance. Given that recent studies have observed differential sensitivity to drugs of abus...
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Article
Tolerance to Repeated Morphine Administration Is Associated with Increased Potency of Opioid Agonists
Tolerance to the pain-relieving effects of opiates limits their clinical use. Although morphine tolerance is associated with desensitization of μ-opioid receptors, the underlying cellular mechanisms are not under...
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Article
Contribution of dopamine receptors to periaqueductal gray-mediated antinociception
Morphine relieves pain, in part, by acting on neurons within the periaqueductal gray (PAG). Given that the PAG contains a subpopulation of dopamine neurons, dopamine may contribute to the antinociceptive effec...
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Reference Work Entry At a glance
Internalization
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Reference Work Entry At a glance
Opioid
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Reference Work Entry At a glance
GPCR
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Reference Work Entry At a glance
μ-Receptor
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Reference Work Entry At a glance
σ-Receptor
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Reference Work Entry At a glance
Voltage-Gated Potassium Channels
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Reference Work Entry At a glance
Downregulation
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Reference Work Entry At a glance
Antinociception
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Reference Work Entry At a glance
Delta-Receptor
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Reference Work Entry At a glance
Enkephalinase
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Reference Work Entry At a glance
Endogenous Opioid
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Reference Work Entry At a glance
G-Protein-Coupled Inwardly Rectifying Potassium Channels
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Reference Work Entry At a glance
Hetero-Oligomers
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Reference Work Entry At a glance
Kappa-Receptor