Definition
The term κ-opioid peptide receptor represents the G-protein-coupled receptor that responds selectively to a group of largely experimental opioid drugs, initially based on ketocyclazocine (hence κ). It is usually named the κ-receptor or KOR. It is expressed in areas of the nervous system that moderately mediate analgesia with a side-effect profile distinct from μ-opioids. The KOP receptor protein is produced by a single gene. When activated, the KOR receptor predominantly transduces cellular actions via inhibitory G-proteins. The electrophysiological consequences of KOP receptor activation are usually inhibitory.
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© 2010 Springer-Verlag Berlin Heidelberg
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Morgan, M.M., Christie, M.J. (2010). Kappa-Receptor. In: Stolerman, I.P. (eds) Encyclopedia of Psychopharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68706-1_1467
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DOI: https://doi.org/10.1007/978-3-540-68706-1_1467
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-68698-9
Online ISBN: 978-3-540-68706-1
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