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Article
Open AccessPlexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics
Infiltrative growth is a major cause of high lethality of malignant brain tumors such as glioblastoma (GBM). We show here that GBM cells upregulate guidance receptor Plexin-B2 to gain invasiveness. Deletion of...
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Article
Open AccessEngineering transferrable microvascular meshes for subcutaneous islet transplantation
The success of engineered cell or tissue implants is dependent on vascular regeneration to meet adequate metabolic requirements. However, development of a broadly applicable strategy for stable and functional ...
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Article
Open AccessBTBR ob/ob mouse model of type 2 diabetes exhibits early loss of retinal function and retinal inflammation followed by late vascular changes
Diabetic retinopathy is increasing in prevalence worldwide and is fast becoming a global epidemic and a leading cause of visual loss. Current therapies are limited, and the development of effective treatments ...
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Article
Printing of Three-Dimensional Tissue Analogs for Regenerative Medicine
Three-dimensional (3-D) cell printing, which can accurately deposit cells, biomaterial scaffolds and growth factors in precisely defined spatial patterns to form biomimetic tissue structures, has emerged as a ...
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Article
Generation of Multi-scale Vascular Network System Within 3D Hydrogel Using 3D Bio-printing Technology
Although 3D bio-printing technology has great potential in creating complex tissues with multiple cell types and matrices, maintaining the viability of thick tissue construct for tissue growth and maturation a...
