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  1. No Access

    Article

    Genome-wide polygenic score to predict chronic kidney disease across ancestries

    Chronic kidney disease (CKD) is a common complex condition associated with high morbidity and mortality. Polygenic prediction could enhance CKD screening and prevention; however, this approach has not been opt...

    Atlas Khan, Michael C. Turchin, Amit Patki, Vinodh Srinivasasainagendra… in Nature Medicine (2022)

  2. No Access

    Article

    The deleterious mutation load is insensitive to recent population history

    Jonathan Pritchard, Guy Sella and colleagues report an analysis using population genetic models to show that recent human demography is likely to have had little impact on the average burden of deleterious mut...

    Yuval B Simons, Michael C Turchin, Jonathan K Pritchard, Guy Sella in Nature Genetics (2014)

  3. No Access

    Article

    Evidence of widespread selection on standing variation in Europe at height-associated SNPs

    Joel Hirschhorn and colleagues examine height-associated SNPs in northern- and southern-European populations. They report evidence of widespread weak selection on standing variation for height in humans.

    Michael C Turchin, Charleston WK Chiang, Cameron D Palmer… in Nature Genetics (2012)

  4. No Access

    Article

    Hundreds of variants clustered in genomic loci and biological pathways affect human height

    A genome-wide association (GWA) study of more than 180,000 individuals has identified hundreds of genetic variants in at least 180 loci associated with adult human height. The loci are not clustered randomly b...

    Hana Lango Allen, Karol Estrada, Guillaume Lettre, Sonja I. Berndt… in Nature (2010)