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Article
Recurrent neural network robust curvature tracking control of tendon-driven continuum manipulators with simultaneous joint stiffness regulation
Continuum manipulators, despite their prominent flexibility and compliance, possess relatively low inherent stiffness and weak load capacity. Realizing simultaneous curvature tracking control and joint stiffne...
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Article
Open AccessMulti-cohort validation of Ascore: an anoikis-based prognostic signature for predicting disease progression and immunotherapy response in bladder cancer
Bladder cancer ranks as the 10th most common cancer worldwide, with deteriorating prognosis as the disease advances. While immune checkpoint inhibitors (ICIs) have shown promise in clinical therapy in both ope...
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Article
Open AccessFeasibility and accuracy of noninvasive continuous hemoglobin monitoring using transesophageal photoplethysmography in porcine model
Continuous and noninvasive hemoglobin (Hb) monitoring during surgery is essential for anesthesiologists to make transfusions decisions. The aim of this study was to investigate the feasibility and accuracy of ...
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Article
Adipose Tissue Exosome circ_sxc Mediates the Modulatory of Adiposomes on Brain Aging by Inhibiting Brain dme-miR-87-3p
Aging of the brain usually leads to the decline of neurological processes and is a major risk factor for various neurodegenerative diseases, including sleep disturbances and cognitive decline. Adipose tissue e...
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Article
Reversal of the levee effect towards sustainable floodplain management
Levees constrain roaring floodwater but are blamed for reducing people’s perception of flood risks and promoting floodplain human settlements unprepared for high-consequence flood events. Yet the interplay bet...
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Article
Open AccessWDR4 promotes the progression and lymphatic metastasis of bladder cancer via transcriptional down-regulation of ARRB2
Lymph node (LN) metastasis is one of the key prognostic factors in bladder cancer, but its underlying mechanisms remain unclear. Here, we found that elevated expression of WD repeat domain 4 (WDR4) in bladder ...
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Article
Open AccessNanovaccine-based strategies for lymph node targeted delivery and imaging in tumor immunotherapy
Therapeutic tumor vaccines have attracted considerable attention in the past decade; they can induce tumor regression, eradicate minimal residual disease, establish lasting immune memory and avoid non-specific...
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Article
Open AccessNanotherapeutics with immunoregulatory functions for the treatment of bacterial infection
The advent of drug-resistant pathogens results in the occurrence of stubborn bacterial infections that cannot be treated with traditional antibiotics. Antibacterial immunotherapy by reviving or activating the ...
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Article
Open AccessFolate-mediated one-carbon metabolism as a potential antifungal target for the sustainable cultivation of microalga Haematococcus pluvialis
Microalgae are widely considered as multifunctional cell factories that are able to transform the photo-synthetically fixed CO2 to numerous high-value compounds, including lipids, carbohydrates, proteins and pigm...
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Article
Open AccessAccelerating the solar-thermal energy storage via inner-light supplying with optical waveguide
Solar-thermal storage with phase-change material (PCM) plays an important role in solar energy utilization. However, most PCMs own low thermal conductivity which restricts the thermal charging rate in bulk sam...
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Article
Photoluminescent gold nanoclusters as two-photon excited ratiometric pH sensor and photoactivated peroxidase
A two-photon excited ratiometric fluorescent pH sensor is reported by combining l-cysteine–protected AuNCs (Cys@AuNCs) with fluorescein isothiocyanate (FITC). Cys@AuNCs were synthesized through a one-step self-re...
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Article
Open AccessUltrasound-guided serratus anterior plane block for transapical transcatheter aortic valve implantation
Reducing postoperative pain due to the thoracotomy incisions in patients undergoing transapical transcatheter aortic valve implantation remains a challenge.
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Article
Open AccessEffects of exercise on inflammatory factors and IGF system in breast cancer survivors: a meta-analysis
At present, there are multiple hypotheses regarding the mechanisms underlying the effect of exercise on the postoperative inflammatory factors and the IGF system among breast cancer patients, especially. To de...
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Article
Open AccessCancer-associated fibroblasts promote the stemness and progression of renal cell carcinoma via exosomal miR-181d-5p
The mechanisms underlying the effects of cancer-associated fibroblasts (CAFs) on cancer stemness and tumor progression in renal cell carcinoma (RCC) have not been elucidated yet. In the present study, we found...
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Article
Open AccessMicrobiota analysis of peri-implant mucositis in patients with periodontitis history
To investigate the bacterial diversity in peri-implant plaques and the effect of periodontitis history on the occurrence of peri-implant mucositis.
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Article
Open AccessComprehensive chemical profiling of volatile constituents of Angong Niuhuang Pill in vitro and in vivo based on gas chromatography coupled with mass spectrometry
Angong Niuhuang Pill (ANP), a renowned precious traditional Chinese medicine prescription, is extensively utilized for the clinical treatment of stroke, meningitis and encephalorrhagia in China. As a classic r...
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Article
Fixed-time anti-saturation compensators based impedance control with finite-time convergence for a free-flying flexible-joint space robot
Aiming at the compliant control problem of a free-flying flexible-joint space robot (FFSR) when it comes in contact with targets or obstacles, a nonsingular composite impedance controller with finite-time conv...
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Article
Open AccessCan the WHO ‘s recommendations of physical activity volume decrease the risk of heart disease in middle and older aged Chinese People: the evidence from a seven year longitudinal survey
At present, there is a lack of direct evidence to confirm whether the recommendations of the World Health Organization can play a role in fitness and disease prevention in the Chinese population. Therefore, we...
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Article
Open AccessLysosomal protein transmembrane 5 promotes lung-specific metastasis by regulating BMPR1A lysosomal degradation
Organotropism during cancer metastasis occurs frequently but the underlying mechanism remains poorly understood. Here, we show that lysosomal protein transmembrane 5 (LAPTM5) promotes lung-specific metastasis ...
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Article
Open AccessAllosteric activation of the metabolic enzyme GPD1 inhibits bladder cancer growth via the lysoPC-PAFR-TRPV2 axis
Bladder cancer is the most common malignant tumor of the urinary system. Surgical resection and chemotherapy are the two mainstream treatments for bladder cancer. However, the outcomes are not satisfactory for...
