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  1. Article

    Open Access

    The role of TLR7 agonists in modulating COVID-19 severity in subjects with loss-of-function TLR7 variants

    We investigate the mechanism associated with the severity of COVID-19 in men with TLR7 mutation. Men with loss-of-function (LOF) mutations in TLR7 had severe COVID-19. LOF mutations in TLR7 increased the risk ...

    Shaik Mohammad Naushad, Gowtham Mandadapu, Mekala Janaki Ramaiah… in Scientific Reports (2023)

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    Article

    Pharmacogenetic determinants of thiopurines in an Indian cohort

    Several genetic variants of thiopurine metabolic pathway are associated with 6-thiopurine-mediated leucopenia. A population-based evaluation of these variants lays the foundation for Pharmacogenetic-guided thi...

    Shaik Mohammad Naushad, Mekala Janaki Ramaiah… in Pharmacological Reports (2021)