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Article
Open AccessIntegrative analysis of single-cell expression data reveals distinct regulatory states in bidirectional promoters
Bidirectional promoters (BPs) are prevalent in eukaryotic genomes. However, it is poorly understood how the cell integrates different epigenomic information, such as transcription factor (TF) binding and chrom...
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Article
Open AccessManananggal - a novel viewer for alternative splicing events
Alternative splicing is an important cellular mechanism that can be analyzed by RNA sequencing. However, identification of splicing events in an automated fashion is error-prone. Thus, further validation is re...
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Article
Open AccessSequence variation between 462 human individuals fine-tunes functional sites of RNA processing
Recent advances in the cost-efficiency of sequencing technologies enabled the combined DNA- and RNA-sequencing of human individuals at the population-scale, making genome-wide investigations of the inter-indiv...
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Article
Open AccessEpigenetic dynamics of monocyte-to-macrophage differentiation
Monocyte-to-macrophage differentiation involves major biochemical and structural changes. In order to elucidate the role of gene regulatory changes during this process, we used high-throughput sequencing to an...
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Article
Transcriptome and genome sequencing uncovers functional variation in humans
Genome sequencing projects are discovering millions of genetic variants in humans, and interpretation of their functional effects is essential for understanding the genetic basis of variation in human traits. ...
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Article
Open AccessA tissue-specific landscape of sense/antisense transcription in the mouse intestine
The intestinal mucosa is characterized by complex metabolic and immunological processes driven highly dynamic gene expression programs. With the advent of next generation sequencing and its utilization for the...
