-
Article
Open AccessEarly vocational rehabilitation and psychological support for trauma patients to improve return to work (the ROWTATE trial): study protocol for an individually randomised controlled multicentre pragmatic trial
Moderately severe or major trauma (injury severity score (ISS) > 8) is common, often resulting in physical and psychological problems and leading to difficulties in returning to work. Vocational rehabilitation...
-
Article
Genomics in active surveillance and post-prostatectomy patients: A review of when and how to use effectively
Prostate cancer (PCa) represents a significant health burden globally, ranking as the most diagnosed cancer among men and a leading cause of cancer-related mortality. Conventional treatment methods such as rad...
-
Article
Open AccessHypoxia-mediated repression of pyruvate carboxylase drives immunosuppression
Metabolic plasticity mediates breast cancer survival, growth, and immune evasion during metastasis. However, how tumor cell metabolism is influenced by and feeds back to regulate breast cancer progression are ...
-
Article
Open AccessCollaboration in Decarbonisation Research: Comparing the UK and European Funding Landscape
Industrial decarbonisation has become an increasingly important policy issue in recent years, as governments and nations aim to tackle the climate crisis. This study makes use of UK research council and Horizo...
-
Article
Open AccessAssessing the potential for improved predictive capacity of antimicrobial resistance in outpatient Staphylococcus aureus isolates using seasonal and spatial antibiograms
While the use of cumulative susceptibility reports, antibiograms, is recommended for improved empiric therapy and antibiotic stewardship, the predictive ability of antibiograms has not been well-studied. While...
-
Article
Persistent IDH mutations are not associated with increased relapse or death in patients with IDH-mutated acute myeloid leukemia undergoing allogeneic hematopoietic cell transplant with post-transplant cyclophosphamide
-
Article
Open AccessLearning representations for image-based profiling of perturbations
Measuring the phenotypic effect of treatments on cells through imaging assays is an efficient and powerful way of studying cell biology, and requires computational methods for transforming images into quantita...
-
Article
Open AccessPolarization properties and Umov effect of human hair
This study delves into the polarization properties of various hair colors using several techniques, including polarization ray tracing, full Stokes, and Mueller matrix imaging. Our analysis involved studying h...
-
Article
Open AccessFeasibility of a novel wearable thermal device for management of bothersome hot flashes in patients with prostate cancer
This single-arm prospective study evaluated the feasibility of a novel wrist-worn thermal device that applies cooling to the inside of the wrist for management of bothersome hot flashes in prostate cancer surv...
-
Article
A new research agenda for African generative AI
The rise of generative AI requires a research agenda grounded in the African context to determine locally relevant strategies for its development and use. With a critical mass of evidence on the risks and bene...
-
Article
Open AccessGenetic stabilization of attenuated oral vaccines against poliovirus types 1 and 3
Vaccination with Sabin, a live attenuated oral polio vaccine (OPV), results in robust intestinal and humoral immunity and has been key to controlling poliomyelitis. As with any RNA virus, OPV evolves rapidly t...
-
Article
Open AccessMass Cytometry reveals unique phenotypic patterns associated with subclonal diversity and outcomes in multiple myeloma
Multiple myeloma (MM) remains an incurable plasma cell (PC) malignancy. Although it is known that MM tumor cells display extensive intratumoral genetic heterogeneity, an integrated map of the tumor proteomic l...
-
Article
Open AccessRevealing the Relational Mechanisms of Research for Development Through Social Network Analysis
Achieving impact through research for development programmes (R4D) requires engagement with diverse stakeholders across the research, development and policy divides. Understanding how such programmes support t...
-
Article
Open AccessPrevalence of occult nodal metastases in squamous cell carcinoma of the temporal bone: a systematic review and meta-analysis
Primary: To determine the rate of occult cervical metastases in primary temporal bone squamous cell carcinomas (TBSSC). Secondary: to perform a subgroup meta-analysis of the risk of occult metastases based on ...
-
Article
Open AccessEvaluating the policy of closing bars and restaurants in Cataluña and its effects on mobility and COVID19 incidence
The world has gone through unprecedented changes since the global pandemic hit. During the early phase of the pandemic, the absence of known drugs or pharmaceutical treatments forced governments to introduce d...
-
Article
Open AccessUnderstanding realistic attacks on airborne collision avoidance systems
Airborne collision avoidance systems provide an onboard safety net should normal air traffic control procedures fail to keep aircraft separated. These systems are widely deployed and have been constantly refin...
-
Protocol
Analysis of Pancreatic Acinar Protein Solubility in Autophagy-Deficient Mice
Autophagy of the endoplasmic reticulum, or ER-phagy, maintains the homeostasis of the secretory pathway. This is particularly prominent in specialized secretory cells such as the acinar cells of the exocrine p...
-
Chapter
Conclusion: Projecting the Child
The child in British cinema is inventive in its ability to engage with the diegetic urban space, able to access physical and emotional landscapes that the adult cannot, appears in a range of generic contexts, ...
-
Chapter
The Child in British Cinema
This work opens with a critical analysis of the existing literature pertaining to the figure of the child onscreen, noting the deeply symbolic power of the child, and acknowledging the way the child manifests ...
-
Chapter
The Child and the City: The Urban Adventurer in Post-war Britain
Using the work of Gilles Deleuze, who suggests the child in Italian neo- realism is a passive observer of the post-war landscape, this chapter creates a contradistinction between the turmoil of the child in ne...
