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Article
Cultivation of previously uncultured microorganisms with a continuous-flow down-flow hanging sponge (DHS) bioreactor, using a syntrophic archaeon culture obtained from deep marine sediment as a case study
In microbiology, cultivation is a central approach for uncovering novel physiology, ecology, and evolution of microorganisms, but conventional methods have left many microorganisms found in nature uncultured. ...
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Article
Open AccessAge-dependent formation of TMEM106B amyloid filaments in human brains
Many age-dependent neurodegenerative diseases, such as Alzheimer’s and Parkinson’s, are characterized by abundant inclusions of amyloid filaments. Filamentous inclusions of the proteins tau, amyloid-β, α-synuc...
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Article
Short hydration with 20 mEq of magnesium supplementation for lung cancer patients receiving cisplatin-based chemotherapy: a prospective study
Intravenous administration of magnesium with a short hydration regimen is recommended for patients receiving high-dose cisplatin to protect against cisplatin-induced nephrotoxicity. However, the optimal dose o...
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Article
Isolation of an archaeon at the prokaryote–eukaryote interface
The origin of eukaryotes remains unclear1–4. Current data suggest that eukaryotes may have emerged from an archaeal lineage known as ‘Asgard’ archaea5,6. Despite the eukaryote-like genomic features that are found...
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Article
Open AccessCultivable microbial community in 2-km-deep, 20-million-year-old subseafloor coalbeds through ~1000 days anaerobic bioreactor cultivation
Recent explorations of scientific ocean drilling have revealed the presence of microbial communities persisting in sediments down to ~2.5 km below the ocean floor. However, our knowledge of these microbial pop...
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Variation of geochemical environments associated with whale-fall biomass mineralization processes in the sediment during the mobile scavenger, enrichment opportunist, and sulfophilic stages
The succession of faunal composition of a whale-fall community is believed to depend on the progress of decomposition of the whale carcass, which itself is dependent on microbial activity in the sediment aroun...
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Incidence of and risk factors associated with nedaplatin-related hypersensitivity reactions
Nedaplatin (NDP)-related hypersensitivity reactions (HSRs) trigger adverse clinical events. Prediction and prevention of NDP-HSRs are thus essential to minimize the risk and maximize the benefit of NDP therapy...
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Article
Mariprofundus micogutta sp. nov., a novel iron-oxidizing zetaproteobacterium isolated from a deep-sea hydrothermal field at the Bayonnaise knoll of the Izu-Ogasawara arc, and a description of Mariprofundales ord. nov. and Zetaproteobacteria classis nov.
A novel iron-oxidizing chemolithoautotrophic bacterium, strain ET2T, was isolated from a deep-sea sediment in a hydrothermal field of the Bayonnaise knoll of the Izu-Ogasawara arc. Cells were bean-shaped, curved ...
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Article
Association of axitinib plasma exposure and genetic polymorphisms of ABC transporters with axitinib-induced toxicities in patients with renal cell carcinoma
Axitinib is a selective tyrosine kinase inhibitor of VEGF receptors, approved for advanced renal cell carcinoma (RCC). Associations between axitinib plasma exposure, genetic polymorphisms of ABC transporters a...
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Article
Open AccessGenotype frequencies for polymorphisms related to chemotherapy-induced nausea and vomiting in a Japanese population
Genotype frequencies for chemotherapy-induced nausea and vomiting (CINV)-related polymorphisms have not yet been reported for Japanese subjects.
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Article
Synthesis of silicon- or carbon-bridged polythiophenes and application to organic thin-film transistors
Silicon- and carbon-bridged polythiophenes, dithienosilole (DTS) and cyclopentadithiophene (DTC) homopolymers with 2-ethylhexyl or n-octyl substituents on the bridging atom, were synthesized and their optical and...
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Article
Open AccessErratum to: A retrospective study to identify risk factors for somnolence and dizziness in patients treated with pregabalin
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Article
Open AccessA retrospective study to identify risk factors for somnolence and dizziness in patients treated with pregabalin
Pregabalin is a therapeutic drug for neuropathic pain that is associated with somnolence and dizziness. These adverse events are often experienced shortly after initiating pregabalin, and may lead to treatment...
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Article
Effects of substituents and molecular weight on the optical, thermal and photovoltaic properties of alternating dithienogermole–dithienylbenzothiadiazole polymers
Dithienogermole-dithienylbenzothiadiazole alternating polymers with high molecular weights were synthesized. Optical properties of the polymers were investigated with respect to UV-Vis absorption spectroscopy,...
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Reference Work Entry In depth
The Family Psychromonadaceae
The family Psychromonadaceae, within the order Alteromonadales, includes only the genus Psychromonas; it is closely related to the three families Pseudoalteromonadaceae, Colwelliaceae, and Idiomarinaceae. The mai...
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Article
Synthesis of poly- and oligo(hydroxyalkanoate)s by deep-sea bacteria, Colwellia spp., Moritella spp., and Shewanella spp
The production of poly(hydroxyalkanoate)s (PHAs) as ecofriendly bioplastics by various deep-sea bacteria (4 types of Colwellia spp., 11 types of Moritella spp., and 18 types of Shewanella spp.) from glucose, fruc...
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Article
A case of fatal intrahepatic cholestasis with primary AL amyloidosis: is early diagnosis possible?
Immunoglobulin light chain-associated (AL) amyloidosis is a multisystemic disorder characterized by extracellular deposition of immunoglobulin light chain produced by a proliferative plasma cell clone. Althoug...
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Article
Synthesis and properties of dithienometallole-pyridinochalcogenadiazole alternate polymers
Donor–acceptor-type alternate polymers composed of dithienometallole (metal=Si or Ge) and pyridinocalcogenadiazole (chalcogen=S or Se) units with the molecular weights of Mn=5700–7400 (Mw/Mn=1.3–1.7) were obtaine...
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Article
Thiofractor thiocaminus gen. nov., sp. nov., a novel hydrogen-oxidizing, sulfur-reducing epsilonproteobacterium isolated from a deep-sea hydrothermal vent chimney in the Nikko Seamount field of the northern Mariana Arc
A novel chemolithoautotrophic hydrogen-oxidizing and sulfur-reducing bacterium, strain 496ChimT, was isolated from a deep-sea hydrothermal vent chimney collected from the hydrothermal field at the summit of Nikko...
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Article
The clinical efficacy and safety of a fluoroquinolone-containing regimen for pulmonary MAC disease
Despite recent advances in chemotherapy, the treatment of pulmonary Mycobacterium avium complex (MAC) disease remains unsatisfactory. Judging from its MIC, fluoroquinolones including gatifloxacin (GFLX) are expec...
