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Article
Open AccessInsights into the dual nature of αB-crystallin chaperone activity from the p.P39L mutant at the N-terminal region
The substitution of leucine to proline at position 39 (p.P39L) in human αB-crystallin (αB-Cry) has been associated with conflicting interpretations of pathogenicity in cataracts and cardiomyopathy. This study ...
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Article
Fibril formation from the amyloid-β peptide is governed by a dynamic equilibrium involving association and dissociation of the monomer
Here I review the molecular mechanisms by which water-soluble monomeric amyloid-β (Aβ) peptides are transformed into well-organized supramolecular complexes called amyloid fibrils. The mechanism of amyloid for...
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Article
Open AccessThe unexpected role of polyubiquitin chains in the formation of fibrillar aggregates
Ubiquitin is known to be one of the most soluble and stably folded intracellular proteins, but it is often found in inclusion bodies associated with various diseases including neurodegenerative disorders and c...
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Article
Open AccessEffects of macromolecular crowding on intracellular diffusion from a single particle perspective
Compared to biochemical reactions taking place in relatively well-defined aqueous solutions in vitro, the corresponding reactions happening in vivo occur in extremely complex environments containing only 60–70...
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Article
Map** the core of the β2-microglobulin amyloid fibril by H/D exchange
Despite numerous efforts, the lack of detailed structural information on amyloid fibrils has hindered clarification of the mechanism of their formation. Here, we describe a novel procedure for characterizing t...
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Article
Structural and kinetic characterization of early folding events in β-lactoglobulin
We have defined the structural and dynamic properties of an early folding intermediate of β-lactoglobulin known to contain non-native α-helical structure. The folding of β-lactoglobulin was monitored over the ...
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Wireless Image Transmit Unit and High Speed Inspection System for Inner Side of Container
The Wireless Image Transmit (WIT) unit is the device to transmit plural video image data through closed pairs of special loop antennas shielded against electromagnetic wave.
