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Article
Therapeutic efficacy of intravenous infusion of mesenchymal stem cells in rat perinatal brain injury
Perinatal brain injury is multifactorial and primarily associated with brain prematurity, inflammation, and hypoxia–ischemia. Although recent advances in perinatal medicine have improved the survival rates of ...
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Article
Open AccessIntravenous infusion of bone marrow-derived mesenchymal stem cells improves tissue perfusion in a rat hindlimb ischemia model
Intravenous infusion of stem cells is a minimally invasive cellular delivery method, though a few have been reported in a critical limb-threatening ischemia (CLTI) animal model or patients. In the present stud...
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Article
Open AccessPossible role of intravenous administration of mesenchymal stem cells to alleviate interstitial cystitis/bladder pain syndrome in a Toll-like receptor-7 agonist-induced experimental animal model in rat
Interstitial cystitis/bladder pain syndrome (IC/BPS) categorized with and without Hunner lesions is a condition that displays chronic pelvic pain related to the bladder with no efficacious treatment options. T...
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Article
Open AccessRepeated infusion of mesenchymal stem cells maintain the condition to inhibit deteriorated motor function, leading to an extended lifespan in the SOD1G93A rat model of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative fatal disorder in which motor neurons within the brain and spinal cord degenerate. A single infusion of mesenchymal stem cells (MSCs) delays disease p...
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Article
Focal brainstem infarction in the adult rat
Animal models are required to study the pathogenesis of brainstem ischemia and to develop new therapeutic approaches to promote functional recovery after ischemia in humans. Few models of brainstem ischemia ar...
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Article
Cerebral aneurysm neck diameter is an independent predictor of progressive occlusion after stent-assisted coiling
Some intracranial aneurysms treated by stent-assisted coiling (SAC) with incomplete occlusion undergo progressive occlusion (PO) during follow-up period. We analyzed the predictors for the occurrence of PO.
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Article
Biological relevance of tissue factor and IL-6 in arteriovenous malformations
Arteriovenous malformations (AVMs) are congenital abnormal vessels that shunt blood directly from the arterial to the venous system without a capillary bed. The underlying pathology of AVMs is not fully unders...
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Article
Preoperative chronic sinusitis as significant cause of postoperative infection and implant loss after sinus augmentation from a lateral approach
Among intra/postoperative complications of sinus augmentation from a lateral approach, postoperative infection and implant loss are particularly important because they have irreversible consequences. The purpo...
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Article
Primary wound closure after tooth extraction for prevention of medication-related osteonecrosis of the jaw in patients under denosumab
Some recent reports have indicated that local infection causes osteonecrosis of the jaw and described that tooth extraction may not be a direct cause of develo** medication-related osteonecrosis of the jaw (...
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Article
Double balloon protection during carotid artery stenting for vulnerable carotid stenosis reduces the incidence of new brain lesions
The use of distal filter protection alone is associated with a high risk of ischemic complications when vulnerable carotid stenosis is treated by carotid artery stenting (CAS). Double balloon protection, a com...
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Article
Comparison of In Vivo with In Vitro Pharmacokinetics of Mercury Between Methylmercury Chloride and Methylmercury Cysteine Using Rats and Caco2 Cells
The in vivo and in vitro pharmacokinetics of mercury (Hg) were compared between methylmercury chloride (MeHg·Cl) and methylmercury cysteine (MeHg-Cys) using rats and Caco2 cells because humans can be exposed t...
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Protocol
A Rat Middle Cerebral Artery Occlusion Model and Intravenous Cellular Delivery
A useful experimental model to study the pathophysiology of cerebral ischemia without craniectomy is the middle cerebral artery occlusion (MCAO) model. In this model, an intraluminal suture is advanced from th...
