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Article
Remarkable response to capmatinib in a patient with intrahepatic cholangiocarcinoma harboring TFG-MET fusion
Dysregulation of mesenchymal-epithelial transition factor (MET) gene due to amplification, mutation, and fusion has been reported in various types of human cancers. Recently, the efficacy of small-molecule tyrosi...
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Article
Response to capmatinib in a patient with neuroendocrine carcinoma of the gallbladder origin harboring MET amplification
Neuroendocrine carcinoma (NEC) of the gallbladder origin is particularly rare, accounting for only 0.38% of primary malignancies of the gallbladder, and standard therapies are limited. The MET gene encodes the ty...
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Article
Open AccessPrevalence of pathogenic germline variants in the circulating tumor DNA testing
Somatic and germline variants are not distinguishable by circulating tumor DNA (ctDNA) testing without analyzing non-tumor samples. Although confirmatory germline testing is clinically relevant, the criteria f...
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Article
Germline sequencing for presumed germline pathogenic variants via tumor-only comprehensive genomic profiling
The European Society for Medical Oncology Precision Medicine Working Group (ESMO-PMWG) published recommendations regarding confirmatory germline testing for presumed germline pathogenic variants (PGPVs) in tum...
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Article
Open AccessInter-assay variability of next-generation sequencing-based gene panels
Tumor heterogeneity has been known to cause inter-assay discordance among next-generation sequencing (NGS) results. However, whether preclinical factors such as sample type, sample quality and analytical featu...
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Article
Open AccessRepeated talaporfin sodium photodynamic therapy for esophageal cancer: safety and efficacy
Talaporfin sodium photodynamic therapy (tPDT) is an effective salvage treatment for local failure after chemoradiotherapy for esophageal cancer. Repeated tPDT could also be indicated for local recurrence or re...
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Article
Qualitative and Quantitative Analysis of Posttreatment Strategy After Endoscopic Resection for Patients with T1 Colorectal Cancer at High Risk of Lymph Node Metastasis
Although endoscopic resection is increasingly performed to treat submucosal invasive colorectal cancer (T1CRC), approximately 10% are at risk of lymph node metastasis. The Japanese Society for Cancer of the Co...
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Article
Open AccessDistinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells
Epidermal growth factor receptor (EGFR) plays a pivotal role in the pathophysiology of esophageal squamous cell carcinoma (ESCC). However, the clinical effects of EGFR inhibitors on ESCC are controversial. Thi...
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Article
Identification of connexins in human oral mucosa and therapeutic effect of irsogladine maleate on aphthous stomatitis
We identified connexins 26 and 32 in human oral mucosa. The presence of the connexins indicates the presence of gap junctions in this tissue. However, immunofluorescence study found no significant differences...
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Chapter and Conference Paper
Rigid Chain Vinyl Polymers from Multi-Substituted Ethylenes
Novel vinyl polymers were synthesized from 1,1- or 1,2-disubstituted and 1,1,2-trisubstituted ethylenes by radical polymerization. The polymers obtained consist of a rigid chain structure on account of the bul...
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Article
Meso and racemo Additions in Propagation for Radical Polymerization of Dialkyl Fumarates I. Stereoregularity of Poly(dialkyl fumarate)s
The polymerization temperature dependence of the stereochemical configuration of some poly(dialkyl fumarate)s as poly(substituted methylene) was investigated by the use of 13C NMR spectroscopy in order to clarify...
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Article
Meso and racemo Additions in Propagation for Radical Polymerization of Dialkyl Fumarates II. Determination of the Absolute Rate Constants
The propagation process in radical polymerization of dialkyl fumarates (DRF) was investigated. The propagation rate constants (kp) for some DRFs were determined by ESR spectroscopy. It was revealed that kp increa...
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Article
Synthesis of high molecular weight poly(dialkyl fumarate)s bearing n-alkyl side chains from poly(di-tert-butyl fumarate) via olefin elimination and reesterification in a one-pot
High molecular weight poly(dialkyl fumarate)s bearing n-alkyl esters such as an octadecyl group were prepared efficiently from poly(di-tert-butyl fumarate) by the one-pot synthesis, i.e. both elimination of isobu...
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Article
Abstracts Of Selected Papers Presented At The 75Th General Meeting Of The Japanese Society Of Gastroenterology March 27–29, 1989 — Yokohama, Japan
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Article
Proceedings of the 69th general meeting from April 11–13, 1983—Osaka, Japan
