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Article
Open AccessGraft protective effects and donor-specific antibody suppression by CD4+CD25+Foxp3+ regulatory T cell induced by HMG-CoA reductase inhibitor rosuvastatin in a murine heart transplant model
We previously demonstrated that the hydroxymethylglutaryl-CoA (HMG-CoA) reductase inhibitor (statins) play an important role in the regulation of alloimmune responses. However, little is known regarding the ef...
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Article
Open AccessEmpirical verification of feeding selectivity of larval and juvenile pelagic fishes using in-situ zooplankton assemblages
Most studies on the feeding ecology of larvae and juveniles of commercially important pelagic fishes have used field-based approaches. However, due to possible biases related to net sampling, it is uncertain w...
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Article
Different responses of herbivore abundance to plant genotypic diversity depending on herbivore host specificity
The response of herbivore abundance to birch genotypic diversity varies depending on the host specificity of the herbivores. Specialist, but not generalist, herbivores were affected by birch genotypic diversity.
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Article
Open AccessIntravascular papillary endothelial hyperplasia of the maxillary sinus extending into the contralateral nasal cavity
Intravascular papillary endothelial hyperplasia (IPEH) predominantly occurs in the subcutaneous and dermal regions and rarely originates from the sinonasal mucosa.
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Article
Open AccessIntranasal administration of ceramide liposome suppresses allergic rhinitis by targeting CD300f in murine models
Allergic rhinitis (AR) is caused by type I hypersensitivity reaction in the nasal tissues. The interaction between CD300f and its ligand ceramide suppresses immunoglobulin E (IgE)-mediated mast cell activation...
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Article
Symptom-based stratification algorithm for heterogeneous symptoms of dry eye disease: a feasibility study
To test the feasibility of a dry eye disease (DED) symptom stratification algorithm previously established for the general population among patients visiting ophthalmologists.
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Article
Impact of antiallergy agents on CPAP therapy and sleep quality with spring pollinosis in Japanese
Allergic rhinitis (AR) is associated with obstructive sleep apnea (OSA) and nasal obstruction causes decreased adherence to continuous positive airway pressure (CPAP). The purpose is to evaluate the effects of...
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Article
Cholesterol-lowering activity of adzuki bean (Vigna angularis) polyphenols
Adzuki beans (ABs; Vigna angularis) were reported to show potential for prevention of cholesterol absorption and lowering of the blood cholesterol level. However, the main active compounds and some cellular effec...
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Article
Open AccessPatient and public involvement in mobile health-based research for hay fever: a qualitative study of patient and public involvement implementation process
Smartphones are being increasingly used for research owing to their multifunctionality and flexibility, and crowdsourced research using smartphone applications (apps) is effective in the early detection and ma...
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Article
Open AccessPrevalence and Characteristics of Dry Eye Disease After Cataract Surgery: A Systematic Review and Meta-Analysis
Dry eye disease (DED) after cataract surgery is associated with various risk factors, while causing a wide range of heterogeneous symptoms including decreased quality of vision. This systematic review and meta...
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Article
Open AccessPositive effects of fast growth on locomotor performance in pelagic fish juveniles
Many laboratory experiments on aquatic vertebrates that inhabit closed water or coastal areas have highlighted negative effects of fast growth on swimming performance. Nonetheless, field studies on pelagic fis...
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Article
Open AccessTDP-43 regulates cholesterol biosynthesis by inhibiting sterol regulatory element-binding protein 2
Dyslipidemia is considered an essential component of the pathological process of amyotrophic lateral sclerosis (ALS), a fatal motor neuron disease. Although TAR DNA Binding Protein 43 kDa (TDP-43) links both f...
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Article
Open AccessAnti-CD80/86 antibodies inhibit inflammatory reaction and improve graft survival in a high-risk murine corneal transplantation rejection model
We investigated the effects of anti-CD80/86 antibodies in a murine high-risk corneal transplantation rejection model. A mixed lymphocyte reaction (MLR) assay was conducted with anti-CD80/86 antibodies. Inflamm...
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Chapter and Conference Paper
Evaluation Method of Gait Motion of a Patient Received Total Knee Arthroplasty Using Correlation Between Measurement Data and Evaluation Score
It is important to evaluate a gait motion in a walking rehabilitation using the simple method. This paper describes the relation between the measurement of the gait motion of the patient received Total Hip Art...
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Article
Open AccessSmartphone-based digital phenoty** for dry eye toward P4 medicine: a crowdsourced cross-sectional study
Multidimensional integrative data analysis of digital phenoty** is crucial for elucidating the pathologies of multifactorial and heterogeneous diseases, such as the dry eye (DE). This crowdsourced cross-sect...
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Article
S100A7 Co-localization and Up-regulation of Filaggrin in Human Sinonasal Epithelial Cells
Filaggrin (FLG) is a protein expressed in the epidermis and involved in the maintenance of the epidermal barrier. However, the expression and localization of FLG in the upper airway remain controversial. The p...
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Article
Induction and expansion of human PRRX1+ limb-bud-like mesenchymal cells from pluripotent stem cells
Current protocols for the differentiation of human pluripotent stem cells (hPSCs) into chondrocytes do not allow for the expansion of intermediate progenitors so as to prospectively assess their chondrogenic p...
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Article
Heterogeneity of eye drop use among symptomatic dry eye individuals in Japan: large-scale crowdsourced research using DryEyeRhythm application
To determine eye drop type and usage frequency and investigate risk factors for no eye drop use in individuals with symptomatic dry eye (DE) in Japan.
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Article
A rare case of Helicobacter pylori-uninfected intramucosal poorly differentiated adenocarcinoma that occurred in the gastric fornix
We report a rare case of undifferentiated-type intramucosal gastric cancer that occurred in the fornix of the stomach without Helicobacter pylori infection, which consisted mainly of poorly differentiated adenoca...
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Chapter and Conference Paper
Development of a Switchable Wearable Robot for Rehabilitation After Surgery of Knee
It is important to give the patient to the suitable rehabilitation after almost surgical operations, however it is hard work for the physical therapist and patient. Therefore, the robot for rehabilitation is d...
