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Article
Open AccessIncreased glucose availability sensitizes pancreatic cancer to chemotherapy
Pancreatic Ductal Adenocarcinoma (PDAC) is highly resistant to chemotherapy. Effective alternative therapies have yet to emerge, as chemotherapy remains the best available systemic treatment. However, the disc...
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Article
Open AccessCrohn’s disease in endoscopic remission, obesity, and cases of high genetic risk demonstrate overlap** shifts in the colonic mucosal-luminal interface microbiome
Crohn’s disease (CD) patients demonstrate distinct intestinal microbial compositions and metabolic characteristics compared to unaffected controls. However, the impact of inflammation and underlying genetic ri...
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Article
Open AccessMetabolomic alterations associated with Behçet’s disease
The diagnosis of Behçet’s disease (BD) remains challenging due to the lack of diagnostic biomarkers. This study aims to identify potential serum metabolites associated with BD and its disease activity.
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Article
Open AccessAbstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015)
O1 Regulation of genes by telomere length over long distances
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Article
The effect of low dose rate on metabolomic response to radiation in mice
Metabolomics has been shown to have utility in assessing responses to exposure by ionizing radiation (IR) in easily accessible biofluids such as urine. Most studies to date from our laboratory and others have ...
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Article
Open AccessIntegrative analysis of the microbiome and metabolome of the human intestinal mucosal surface reveals exquisite inter-relationships
Consistent compositional shifts in the gut microbiota are observed in IBD and other chronic intestinal disorders and may contribute to pathogenesis. The identities of microbial biomolecular mechanisms and meta...
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Article
DFT Study of Endohedral Atoms Effect on Electrophilicity of B16N16 Boron Nitride Nanocage: Comparative Analyses
Endohedral derivatives of B16N16 nanocage (M@B16N16, M = Li+, Na+, K+, Mg2+, Ne, O2−, S2−, F−, Cl−) and its iso-electronic fullerne M@C32 have been employed to investigate the relation between the trapped atom/io...
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Article
Purification and characterization of Thermotoga maritima homoserine transsuccinylase indicates it is a transacetylase
The methionine biosynthetic pathway found in bacteria is controlled at the first step, acylation of the γ-hydroxyl of homoserine. This reaction is catalyzed by one of two unique enzymes, homoserine transacetyl...
