25 Result(s)
within
Mary N. Sheppard
English
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Article
Open AccessGenetically determined cardiomyopathies at autopsy: the pivotal role of the pathologist in establishing the diagnosis and guiding family screening
Cardiomyopathies (CMP) comprise a heterogenous group of diseases affecting primarily the myocardium, either genetic and/or acquired in origin. While many classification systems have been proposed in the clinic...
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First Identified Case of Fatal Fulminant Necrotizing Eosinophilic Myocarditis Following the Initial Dose of the Pfizer-BioNTech mRNA COVID-19 Vaccine (BNT162b2, Comirnaty): an Extremely Rare Idiosyncratic Hypersensitivity Reaction
Transient myopericarditis has been recognised as an uncommon and usually mild adverse event predominantly linked to mRNA-based COVID-19 vaccines. These have mostly occurred in young males after the second dose...
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Correction to: Cardiac hypertrophy at autopsy
A correction to this paper has been published: https://doi.org/10.1007/s00428-021-03118-1
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An updated approach to sudden cardiac death, the AECVP perspective
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Article
Open AccessCardiac hypertrophy at autopsy
Since cardiac hypertrophy may be considered a cause of death at autopsy, its assessment requires a uniform approach. Common terminology and methodology to measure the heart weight, size, and thickness as well ...
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Chapter
Mitral Valve Pathology
The mitral valve is composed of leaflets, cords, and papillary muscles which must work in combination for the valve to function properly. The valve leaflets have three distinct layers, the atrialis, the spongi...
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Article
Open AccessAutopsy in adults with congenital heart disease (ACHD)
The adult congenital heart diseases (ACHD) population is exceeding the pediatric congenital heart diseases (CHD) population and is progressively expanding each year, representing more than 90% of patients with...
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Article
Open AccessDiagnosis of myocardial infarction at autopsy: AECVP reappraisal in the light of the current clinical classification
Ischemic heart disease is one of the leading causes of morbidity and death worldwide. Consequently, myocardial infarctions are often encountered in clinical and forensic autopsies, and diagnosis can be challen...
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Article
Open AccessNext-generation sequencing using microfluidic PCR enrichment for molecular autopsy
We aimed to determine the mutation yield and clinical applicability of “molecular autopsy” following sudden arrhythmic death syndrome (SADS) by validating and utilizing low-cost high-throughput technologies: F...
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Chapter
The Normal Aorta and Changes with Age
The aorta is the blood vessel responsible for delivering blood from the heart to the systemic circulation. The aortic wall is a highly dynamic and tightly regulated structure that performs sophisticated functi...
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Chapter
Aortic Connective Tissue Histopathology
Aortic disease is a significant cause of death in developed countries. The most common aortic diseases are aneurysm, dissection and atheroma. The microstructure of the aortic medial tissue shows alteration of ...
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Chapter
Genetics and Genomics of Sudden Unexplained Cardiac Death
The aetiology of sudden cardiac death (SCD) and sudden arrhythmic death syndrome (SADS) is not fully explored. Expert cardiac pathology and detailed familial clinical evaluation can identify an inherited cardi...
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Article
Open AccessGuidelines for autopsy investigation of sudden cardiac death: 2017 update from the Association for European Cardiovascular Pathology
Although sudden cardiac death (SCD) is one of the most important modes of death in Western countries, pathologists and public health physicians have not given this problem the attention it deserves. New method...
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Open AccessSudden unexplained death in alcohol misuse (SUDAM) patients have different characteristics to those who died from sudden arrhythmic death syndrome (SADS)
There is growing awareness of sudden unexplained death in alcohol misuse (SUDAM) in which there is no obvious cause of death, no evidence of acute alcohol toxicity or alcoholic ketoacidosis, and the heart is m...
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Aneurysmal dilatation of the aortic sinuses of Valsalva — beyond Marfan syndrome: a single centre experience and review of the literature
Aneurysmal dilatation of the aortic sinuses of Valsalva has been most extensively documented in the setting of aortopathies, particularly Marfan syndrome. On the other hand, there is limited data in the litera...
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Article
Open AccessCalibration of myocardial T2 and T1 against iron concentration
The assessment of myocardial iron using T2* cardiovascular magnetic resonance (CMR) has been validated and calibrated, and is in clinical use. However, there is very limited data assessing the relaxation param...
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Sudden cardiac death caused by coronary vasculitis
Coronary vasculitis is a rare and diagnostically challenging cause of sudden cardiac death (SCD). There are currently no large-scale series on this rare entity. A retrospective non-case–control observational s...
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Cardiac sarcoidosis and sudden death. The heart may look normal or mimic other cardiomyopathies
Cardiac sarcoidosis has been known to give rise to heart failure, arrhythmias and sudden cardiac death. We have a large database of sudden cardiac death cases at the CRY Centre for Cardiac Pathology at Imperia...
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Cystic tumour of the atrioventricular node: three cases of sudden death
Cystic tumour of the atrioventricular nodal region is a rare primary cardiac tumour that can cause sudden death. Antemortem diagnosis and successful excision of this type of tumour are extremely rare. Three ca...
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Open AccessCombined imaging, computational and histological analysis of a ruptured carotid plaque: A patient-specific analysis
Rupture of carotid plaques is an important cause of cerebrovascular events. Several factors, including wall shear stress (WSS), plaque morphology and peak cap stress, have been associated with plaque vulnerabi...
