Functional Imaging and Modeling of the Heart
12th International Conference, FIMH 2023, Lyon, France, June 19–22, 2023, Proceedings
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Chapter and Conference Paper
On the Possibility of Estimating Myocardial Fiber Architecture from Cardiac Strains
The myocardium is composed of a complex network of contractile myofibers that are organized in such a way as to produce efficient contraction and relaxation of the heart. The myofiber architecture in the myoca...
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Chapter and Conference Paper
Assessment of the Evolution of Temporal Segmental Strain in a Longitudinal Study of Myocardial Infarction
In this study, we propose an approach for the assessment of the evolution of heart function in a population of ST-elevation myocardial infarction (STEMI) patients. The patients were imaged using cine MRI with ...
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Book and Conference Proceedings
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Article
Open AccessPrecision delivery of liquid therapy into the arterial wall for the treatment of peripheral arterial disease
Perfusion catheters have recently emerged as a novel approach to deliver liquid anti-proliferative agents into flow obstructed arterial segments. The purpose of this study was to determine the impact of lumina...
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Article
Influence of Collaterals on True FFR Prediction for a Left Main Stenosis with Concomitant Lesions: An In Vitro Study
With the aim of assisting interventional cardiologists during decision making for revascularization, reduced-order (0D) approaches have been developed to predict the true fractional flow reserve (FFRTrue) of indi...
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Chapter and Conference Paper
Comparison of Different Strain-Based Parameters to Identify Human Left Ventricular Myocardial Infarct During Diastole: A 3D Finite-Element Study
Assessment of myocardial damage is important to obtain an accurate prognosis after myocardial infarction. Myocardial strains have been shown to be good indicators of the myocardial viability. Strain analysis h...
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Chapter and Conference Paper
Strain-Based Parameters for Infarct Localization: Evaluation via a Learning Algorithm on a Synthetic Database of Pathological Hearts
Localization of infarcted regions is essential to determine the most appropriate treatment for patients with cardiac ischemia. Myocardial strain partially reflects the location of infarcted regions, which demo...
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Article
Biomechanics of Atherosclerotic Coronary Plaque: Site, Stability and In Vivo Elasticity Modeling
Coronary atheroma develop in local sites that are widely variable among patients and are considerably variable in their vulnerability for rupture. This article summarizes studies conducted by our collaborative...
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Article
Elucidating atherosclerotic vulnerable plaque rupture by modeling cross substitution of ApoE−/− mouse and human plaque components stiffnesses
The structure of mouse atherosclerotic lesions may differ from that of humans, and mouse atherosclerotic plaques do not rupture except in some specific locations such as the brachiocephalic artery. Recently, o...
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Article
Open AccessThe feasibility of 350 micron spatial resolution coronary MRA at 3T in humans
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Article
Open AccessCombined imaging, computational and histological analysis of a ruptured carotid plaque: A patient-specific analysis
Rupture of carotid plaques is an important cause of cerebrovascular events. Several factors, including wall shear stress (WSS), plaque morphology and peak cap stress, have been associated with plaque vulnerabi...
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Article
High-Affinity αvβ3 Integrin Targeted Optical Probe as a New Imaging Biomarker for Early Atherosclerosis: Initial Studies in Watanabe Rabbits
A newly developed synthetic αvβ3 integrin targeted optical probe (ITOP) has been demonstrated to target cancer cells, in vivo. Compared to the commercially available cyclic peptide c[RGDfv], this optical probe ha...
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Chapter
In Vitro Tubulogenesis of Endothelial Cells: Analysis of a Bifurcation Process Controlled by a Mechanical Switch
The formation of new blood vessels in vivo is a multistep process in which sprouting endothelial cells (ECs) form tubes with lumina, these tubes being additionally organized as capillary networks. In vitro models...
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Article
An Integrative Model of the Self-Sustained Oscillating Contractions of Cardiac Myocytes
Computational cell models appear as necessary tools for handling the complexity of intracellular cell dynamics, especially calcium dynamics. However, while oscillating intracellular calcium oscillations are we...
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Article
Computation of Adherent Cell Elasticity for Critical Cell-Bead Geometry in Magnetic Twisting Experiments
Quantification of the cell elastic modulus is a central issue of micromanipulation techniques used to analyze the mechanical properties of living adherent cells. In magnetic twisting cytometry (MTC), magnetic ...
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Article
Transmission of Mechanical Stresses within the Cytoskeleton of Adherent Cells: A Theoretical Analysis Based on a Multi-Component Cell Model
How environmental mechanical forces affect cellular functions is a central problem in cell biology. Theoretical models of cellular biomechanics provide relevant tools for understanding how the contributions of...
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Chapter and Conference Paper
Indentation for Estimating the Human Tongue Soft Tissues Constitutive Law: Application to a 3D Biomechanical Model
A 3D biomechanical model of the tongue is presented here. Its goal is to evaluate the speech control model. This model was designed considering three constraints: speech movement speed, tongue movements and to...
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Chapter and Conference Paper
Does the Collagen Network Contribute to Normal Systolic Left Ventricular Wall Thickening? A Theoretical Study in Continuum Mechanics
Studies in mammalian hearts shown that left ventricular wall thickening is an important mechanism for normal systolic ejection, and that during contraction the myocardium develops a significant stress in the m...
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Chapter
Right and Left Ventricle Interaction and Remodeling in Congenital Heart Disease
A biomechanical model of the left ventricle (LV) using loading conditions and short-axis echocardiographic shape information predicts significant differences in fiber disorganization and contractility among no...
