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Article
Open AccessThe potential role of ocular and otolaryngological mucus proteins in myalgic encephalomyelitis/chronic fatigue syndrome
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating illness associated with a constellation of other symptoms. While the most common symptom is unrelenting fatigue, many individuals a...
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Article
Open AccessThe impact of post-traumatic stress on quality of life and fatigue in women with Gulf War Illness
Gulf War Illness (GWI) is a chronic, multi-symptomatic disorder characterized by fatigue, muscle pain, cognitive problems, insomnia, rashes, and gastrointestinal issues affecting an estimated 30% of the ~ 750,...
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Protocol
Psychoneuroimmunology and Natural Killer Cells: The Chromium-Release Whole-Blood Assay
Natural killer (NK) cells are an essential component of innate immunity. These lymphocytes are also sensitive barometers of the effects of endogenous and exogenous stressors on the immune system. This chapter ...
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Protocol
Exploring the Diagnostic Potential of Immune Biomarker Co-expression in Gulf War Illness
Complex disorders like Gulf War illness (GWI) often defy diagnosis on the basis of a single biomarker and may only be distinguishable by considering the co-expression of multiple markers measured in response t...
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Protocol
Increasing Resilience to Traumatic Stress: Understanding the Protective Role of Well-Being
The brain maintains homeostasis in part through a network of feedback and feed-forward mechanisms, where neurochemicals and immune markers act as mediators. Using a previously constructed model of biobehaviora...
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Protocol
Breaking Away: The Role of Homeostatic Drive in Perpetuating Depression
We propose that the complexity of regulatory interactions modulating brain neurochemistry and behavior is such that multiple stable responses may be supported, and that some of these alternate regulatory progr...
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Article
Change in urinary cortisol excretion mediates the effect of angry/hostile mood on 9 month diastolic blood pressure in HIV+ adults
Cardiovascular disease is a growing concern in HIV disease management and nearly 1 out of 3 persons living with the virus is hypertensive. Biobehavioral factors such as anger, hostility, and HPA axis reactivit...
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Article
Psychological Distress Mediates the Effect of Alexithymia on 2-Year Change in HIV Viral Load
Individuals with trait alexithymia (AL) display poor cognitive assimilation of thoughts, feelings, and emotions. This may result in the persistence of stress, anxiety, and depressive disorders. The cumulative ...
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Article
Open AccessTracking post-infectious fatigue in clinic using routine Lab tests
While biomarkers for chronic fatigue syndrome (CFS) are beginning to emerge they typically require a highly specialized clinical laboratory. We hypothesized that subsets of commonly measured laboratory markers...
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Article
Open AccessIllness progression in chronic fatigue syndrome: a shifting immune baseline
Validation of biomarkers for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) across data sets has proven disappointing. As immune signature may be affected by many factors, our objective was to exp...
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Article
Alexithymia, Assertiveness and Psychosocial Functioning in HIV: Implications for Medication Adherence and Disease Severity
Psychosocial function and adherence to antiretroviral regimen are key factors in human immunodeficiency virus (HIV) disease management. Alexithymia (AL) is a trait deficit in the ability to identify and descri...
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Article
Open AccessUsing gene expression signatures to identify novel treatment strategies in gulf war illness
Gulf War Illness (GWI) is a complex multi-symptom disorder that affects up to one in three veterans of this 1991 conflict and for which no effective treatment has been found. Discovering novel treatment strate...
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Article
Open AccessA comparison of sex-specific immune signatures in Gulf War illness and chronic fatigue syndrome
Though potentially linked to the basic physiology of stress response we still have no clear understanding of Gulf War Illness (GWI), a debilitating condition presenting complex immune, endocrine and neurologic...
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Article
Open AccessCytokine expression profiles of immune imbalance in post-mononucleosis chronic fatigue
As Chronic Fatigue Syndrome (CFS) has been known to follow Epstein-Bar virus (EBV) and other systemic infections; our objective was to describe differences in immune activation in post-infective CFS (PI-CFS) p...
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Protocol
Psychoneuroimmunology and Natural Killer Cells: The Chromium Release Whole Blood Assay
Natural killer (NK) cells are an essential component of innate immunity. These lymphocytes are also sensitive barometers of the effects of endogenous and exogenous stressors on the immune system. This chapter ...
-
Protocol
Exploring the Diagnostic Potential of Immune Biomarker Coexpression in Gulf War Illness
Complex disorders like Gulf War Illness (GWI) often defy diagnosis on the basis of a single biomarker and may only be distinguishable by considering the coexpression of multiple markers measured in response to...
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Article
View of God as benevolent and forgiving or punishing and judgmental predicts HIV disease progression
This study assessed the predictive relationship between View of God beliefs and change in CD4-cell and Viral Load (VL) in HIV positive people over an extended period. A diverse sample of HIVseropositive partic...
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Article
Open AccessPlasma cytokines in women with chronic fatigue syndrome
Chronic Fatigue Syndrome (CFS) studies from our laboratory and others have described cytokine abnormalities. Other studies reported no difference between CFS and controls. However, methodologies varied widely ...
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Article
Depressive Symptoms and Cervical Neoplasia in HIV+ Low-Income Minority Women with Human Papillomavirus Infection
Prior work has related elevated life stress to greater risk of cervical neoplasia in women with human immunodeficiency virus (HIV) and human papillomavirus (HPV).
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Article
Open AccessImpaired immune function in Gulf War Illness
Gulf War Illness (GWI) remains a serious health consequence for at least 11,000 veterans of the first Gulf War in the early 1990s. Our understanding of the health consequences that resulted remains inadequate,...
