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Chapter and Conference Paper
Incorporating Regional Brain Connectivity Profiles into the Inference of Exposure-Related Neurobehavioral Burden in Explosive Ordnance Disposal Veterans
Conventional data-driven investigation into novel and complex health outcomes is often impeded by sparse and incomplete data fragmented across platforms and studies. To address this, we propose a knowledge-dri...
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Chapter and Conference Paper
Map** Signaling Mechanisms in Neurotoxic Injury from Sparsely Sampled Data Using a Constraint Satisfaction Framework
Gulf War Illness (GWI) is a poorly understood exposure-induced neuroinflammatory disorder where complexity and the high cost of animal exposure studies has led to fragmented and sparse data sets incompatible w...
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Article
Open AccessOld drugs, new tricks: leveraging known compounds to disrupt coronavirus-induced cytokine storm
A major complication in COVID-19 infection consists in the onset of acute respiratory distress fueled by a dysregulation of the host immune network that leads to a run-away cytokine storm. Here, we present an ...
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Article
Open AccessHigh-fidelity discrete modeling of the HPA axis: a study of regulatory plasticity in biology
The hypothalamic-pituitary-adrenal (HPA) axis is a central regulator of stress response and its dysfunction has been associated with a broad range of complex illnesses including Gulf War Illness (GWI) and Chro...
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Article
Open AccessEpigenetic impacts of stress priming of the neuroinflammatory response to sarin surrogate in mice: a model of Gulf War illness
Gulf War illness (GWI) is an archetypal, medically unexplained, chronic condition characterised by persistent sickness behaviour and neuroimmune and neuroinflammatory components. An estimated 25–32% of the ove...
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Protocol
Psychoneuroimmunology and Natural Killer Cells: The Chromium-Release Whole-Blood Assay
Natural killer (NK) cells are an essential component of innate immunity. These lymphocytes are also sensitive barometers of the effects of endogenous and exogenous stressors on the immune system. This chapter ...
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Protocol
Exploring the Diagnostic Potential of Immune Biomarker Co-expression in Gulf War Illness
Complex disorders like Gulf War illness (GWI) often defy diagnosis on the basis of a single biomarker and may only be distinguishable by considering the co-expression of multiple markers measured in response t...
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Protocol
Increasing Resilience to Traumatic Stress: Understanding the Protective Role of Well-Being
The brain maintains homeostasis in part through a network of feedback and feed-forward mechanisms, where neurochemicals and immune markers act as mediators. Using a previously constructed model of biobehaviora...
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Protocol
Breaking Away: The Role of Homeostatic Drive in Perpetuating Depression
We propose that the complexity of regulatory interactions modulating brain neurochemistry and behavior is such that multiple stable responses may be supported, and that some of these alternate regulatory progr...
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Article
Open AccessA case matched study examining the reliability of using ImPACT to assess effects of multiple concussions
Approximately 3.8 million sport and recreational concussions occur per year, creating a need for accurate diagnosis and management of concussions. Researchers and clinicians are exploring the potential dose-re...
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Article
Open AccessTracking post-infectious fatigue in clinic using routine Lab tests
While biomarkers for chronic fatigue syndrome (CFS) are beginning to emerge they typically require a highly specialized clinical laboratory. We hypothesized that subsets of commonly measured laboratory markers...
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Article
Open AccessIllness progression in chronic fatigue syndrome: a shifting immune baseline
Validation of biomarkers for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) across data sets has proven disappointing. As immune signature may be affected by many factors, our objective was to exp...
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Article
Open AccessUsing gene expression signatures to identify novel treatment strategies in gulf war illness
Gulf War Illness (GWI) is a complex multi-symptom disorder that affects up to one in three veterans of this 1991 conflict and for which no effective treatment has been found. Discovering novel treatment strate...
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Article
Open AccessA comparison of sex-specific immune signatures in Gulf War illness and chronic fatigue syndrome
Though potentially linked to the basic physiology of stress response we still have no clear understanding of Gulf War Illness (GWI), a debilitating condition presenting complex immune, endocrine and neurologic...
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Article
Open AccessCytokine expression profiles of immune imbalance in post-mononucleosis chronic fatigue
As Chronic Fatigue Syndrome (CFS) has been known to follow Epstein-Bar virus (EBV) and other systemic infections; our objective was to describe differences in immune activation in post-infective CFS (PI-CFS) p...
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Protocol
Psychoneuroimmunology and Natural Killer Cells: The Chromium Release Whole Blood Assay
Natural killer (NK) cells are an essential component of innate immunity. These lymphocytes are also sensitive barometers of the effects of endogenous and exogenous stressors on the immune system. This chapter ...
-
Protocol
Exploring the Diagnostic Potential of Immune Biomarker Coexpression in Gulf War Illness
Complex disorders like Gulf War Illness (GWI) often defy diagnosis on the basis of a single biomarker and may only be distinguishable by considering the coexpression of multiple markers measured in response to...
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Article
Open AccessUsing an agent-based model to analyze the dynamic communication network of the immune response
The immune system behaves like a complex, dynamic network with interacting elements including leukocytes, cytokines, and chemokines. While the immune system is broadly distributed, leukocytes must communicate ...
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Article
Open AccessPlasma neuropeptide Y: a biomarker for symptom severity in chronic fatigue syndrome
Chronic fatigue syndrome (CFS) is a complex, multi-symptom illness with a multisystem pathogenesis involving alterations in the nervous, endocrine and immune systems.
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Article
Open AccessEvidence of inflammatory immune signaling in chronic fatigue syndrome: A pilot study of gene expression in peripheral blood
Genomic profiling of peripheral blood reveals altered immunity in chronic fatigue syndrome (CFS) however interpretation remains challenging without immune demographic context. The object of this work is to ide...
