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  1. Article

    Open Access

    PKC regulates αKlotho gene expression in MDCK and NRK-52E cells

    Particularly expressed in the kidney, αKlotho is a transmembrane protein that acts together with bone hormone fibroblast growth factor 23 (FGF23) to regulate renal phosphate and vitamin D homeostasis. Soluble ...

    Lisa Wolf, Julia Vogt, Jana Alber… in Pflügers Archiv - European Journal of Phys… (2024)

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  2. Article

    Open Access

    Myostatin regulates the production of fibroblast growth factor 23 (FGF23) in UMR106 osteoblast–like cells

    Myostatin is a signaling molecule produced by skeletal muscle cells (myokine) that inhibits muscle hypertrophy and has further paracrine and endocrine effects in other organs including bone. Myostatin binds to...

    Franz Ewendt, Martina Feger, Michael Föller in Pflügers Archiv - European Journal of Phys… (2021)

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  3. Article

    Open Access

    Glucocorticoids dexamethasone and prednisolone suppress fibroblast growth factor 23 (FGF23)

    Fibroblast growth factor 23 (FGF23) is a hormone mainly secreted by bone cells. Its most prominent effects are the regulation of renal phosphate reabsorption and calcitriol (active vitamin D, 1,25(OH)2D3) formati...

    Martina Feger, Franz Ewendt, Jörg Strotmann… in Journal of Molecular Medicine (2021)

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  4. No Access

    Article

    Peroxisome proliferator–activated receptor α (PPARα)–dependent regulation of fibroblast growth factor 23 (FGF23)

    Bone cells secrete fibroblast growth factor 23 (FGF23), a hormone that inhibits the synthesis of active vitamin D (1,25(OH)2D3) and induces phosphate excretion in the kidney. In addition, it exerts paracrine effe...

    Franz Ewendt, Frank Hirche, Martina Feger… in Pflügers Archiv - European Journal of Phys… (2020)