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Article
Open AccessPKC regulates αKlotho gene expression in MDCK and NRK-52E cells
Particularly expressed in the kidney, αKlotho is a transmembrane protein that acts together with bone hormone fibroblast growth factor 23 (FGF23) to regulate renal phosphate and vitamin D homeostasis. Soluble ...
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Article
Open AccessOncostatin M is a regulator of fibroblast growth factor 23 (FGF23) in UMR106 osteoblast-like cells
Renal phosphate and vitamin D metabolism is under the control of fibroblast growth factor 23 (FGF23), an endocrine and paracrine factor predominantly produced in bone. FGF23 formation is stimulated by active v...
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Article
Open AccessMyostatin regulates the production of fibroblast growth factor 23 (FGF23) in UMR106 osteoblast–like cells
Myostatin is a signaling molecule produced by skeletal muscle cells (myokine) that inhibits muscle hypertrophy and has further paracrine and endocrine effects in other organs including bone. Myostatin binds to...
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Article
Open AccessGlucocorticoids dexamethasone and prednisolone suppress fibroblast growth factor 23 (FGF23)
Fibroblast growth factor 23 (FGF23) is a hormone mainly secreted by bone cells. Its most prominent effects are the regulation of renal phosphate reabsorption and calcitriol (active vitamin D, 1,25(OH)2D3) formati...
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Article
Open AccessDJ-1 (Park7) affects the gut microbiome, metabolites and the development of innate lymphoid cells (ILCs)
The proper communication between gut and brain is pivotal for the maintenance of health and, dysregulation of the gut-brain axis can lead to several clinical disorders. In Parkinson’s disease (PD) 85% of all p...
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Article
Peroxisome proliferator–activated receptor α (PPARα)–dependent regulation of fibroblast growth factor 23 (FGF23)
Bone cells secrete fibroblast growth factor 23 (FGF23), a hormone that inhibits the synthesis of active vitamin D (1,25(OH)2D3) and induces phosphate excretion in the kidney. In addition, it exerts paracrine effe...
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Article
Open AccessA high-fat diet stimulates fibroblast growth factor 23 formation in mice through TNFα upregulation
Bone-derived fibroblast growth factor 23 (FGF23) is a hormone that suppresses renal phosphate reabsorption and calcitriol (i.e., 1,25(OH)2D3) formation together with its co-receptor Klotho. FGF23- or Klotho-defic...
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Article
Open AccessThe production of fibroblast growth factor 23 is controlled by TGF-β2
Transforming growth factor-β (TGF-β) is a cytokine produced by many cell types and implicated in cell growth, differentiation, apoptosis, and inflammation. It stimulates store-operated calcium entry (SOCE) thr...
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Article
Open AccessInvolvement Of Vascular Aldosterone Synthase In Phosphate-Induced Osteogenic Transformation Of Vascular Smooth Muscle Cells
Vascular calcification resulting from hyperphosphatemia is a major determinant of mortality in chronic kidney disease (CKD). Vascular calcification is driven by aldosterone-sensitive osteogenic transformation ...
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Article
Sgk1 sensitivity of Na+/H+ exchanger activity and cardiac remodeling following pressure overload
Sustained increase of cardiac workload is known to trigger cardiac remodeling with eventual development of cardiac failure. Compelling evidence points to a critical role of enhanced cardiac Na+/H+ exchanger (NHE1...
