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Article
Open AccessAnnotated expression and activity data for murine recombinase alleles and transgenes: the CrePortal resource
Recombinase alleles and transgenes can be used to facilitate spatio-temporal specificity of gene disruption or transgene expression. However, the versatility of this in vivo recombination system relies on havi...
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Article
Open AccessMouse Genome Informatics (MGI): latest news from MGD and GXD
The Mouse Genome Informatics (MGI) database system combines multiple expertly curated community data resources into a shared knowledge management ecosystem united by common metadata annotation standards. MGI’s...
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Chapter
The Mouse Gene Expression Database (GXD)
The Gene Expression Database (GXD) is an extensive, highly curated, and freely available community resource of mouse gene expression information. Its primary emphasis is on endogenous gene expression during mo...
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Protocol
Mouse Genome Informatics (MGI): Resources for Mining Mouse Genetic, Genomic, and Biological Data in Support of Primary and Translational Research
The Mouse Genome Informatics (MGI), resource (www.informatics.jax.org) has existed for over 25 years, and over this time its data content, informatics infras...
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Article
Open AccessMouse anatomy ontologies: enhancements and tools for exploring and integrating biomedical data
Mouse anatomy ontologies provide standard nomenclature for describing normal and mutant mouse anatomy, and are essential for the description and integration of data directly related to anatomy such as gene exp...
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Article
Open AccessGXD: a community resource of mouse Gene Expression Data
The Gene Expression Database (GXD) is an extensive, easily searchable, and freely available database of mouse gene expression information (www.informatics.jax.org/expression.shtml
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Article
Open AccessOrthology for comparative genomics in the mouse genome database
The mouse genome database (MGD) is the model organism database component of the mouse genome informatics system at The Jackson Laboratory. MGD is the international data resource for the laboratory mouse and fa...
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Article
Open AccessMouse Genome Informatics (MGI): reflecting on 25 years
From its inception in 1989, the mission of the Mouse Genome Informatics (MGI) resource remains to integrate genetic, genomic, and biological data about the laboratory mouse to facilitate the study of human hea...
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Article
Open AccessEMAP/EMAPA ontology of mouse developmental anatomy: 2013 update
The Edinburgh Mouse Atlas Project (EMAP) ontology of mouse developmental anatomy provides a standard nomenclature for describing normal and mutant mouse embryo anatomy. The ontology forms the core of the EMAP ...
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Article
BioGPS and GXD: mouse gene expression data—the benefits and challenges of data integration
Mouse gene expression data are complex and voluminous. To maximize the utility of these data, they must be made readily accessible through databases, and those resources need to place the expression data in th...
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Article
Open AccessThe mammalian gene function resource: the international knockout mouse consortium
In 2007, the International Knockout Mouse Consortium (IKMC) made the ambitious promise to generate mutations in virtually every protein-coding gene of the mouse genome in a concerted worldwide action. Now, 5 y...
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Article
Minimum information specification for in situ hybridization and immunohistochemistry experiments (MISFISHIE)
One purpose of the biomedical literature is to report results in sufficient detail that the methods of data collection and analysis can be independently replicated and verified. Here we present reporting guide...
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Article
Open AccessThe Adult Mouse Anatomical Dictionary: a tool for annotating and integrating data
We have developed an ontology to provide standardized nomenclature for anatomical terms in the postnatal mouse. The Adult Mouse Anatomical Dictionary is structured as a directed acyclic graph, and is organized...
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Article
Gene Ontology: tool for the unification of biology
Genomic sequencing has made it clear that a large fraction of the genes specifying the core biological functions are shared by all eukaryotes. Knowledge of the biological role of such shared proteins in one or...
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Chapter
The Mouse Genome Database and The Gene Expression Database: Genotype to Phenotype
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Chapter
The Uvomorulin—Catenin Complex
Cadherins are a protein family of Ca2+-dependent transmembrane-type cell adhesion molecules. They mediate Ca2+-dependent cell-cell adhesion by homophilic binding. All solid tissues in vertebrates express some Cad...
