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Article
Preschoolers’ Self-Regulation: Private Speech in Cognitive and Emotion Contexts
Self-regulation includes the ability to control one’s behavior as needed to meet social expectations and is associated with adaptive developmental outcomes. One tool for self-regulation is private speech; howe...
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Article
Validation of a Chinese translation of the Parents’ Beliefs About Children’s Emotions questionnaire and measurement invariance across Chinese and US mothers
Both theoretical and empirical work support variation in maternal beliefs about children’s emotions across sociocultural contexts. Cross-cultural comparisons require valid scales measuring mothers’ beliefs abo...
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Article
Open AccessThe case for standardizing gene nomenclature in vertebrates
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Article
Open AccessAnnotated expression and activity data for murine recombinase alleles and transgenes: the CrePortal resource
Recombinase alleles and transgenes can be used to facilitate spatio-temporal specificity of gene disruption or transgene expression. However, the versatility of this in vivo recombination system relies on havi...
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Article
Know Your Model: A brief history of making mutant mouse genetic models
For over a century, researchers have used mice as models and adapted many new methods to create novel mutations in them. In the past 100+ years, we have gone from breeding strains for selected traits to induci...
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Article
Know Your Model: Microbiota & phenotypes
Host genetics, housing conditions, and antibiotic treatments impact microbiota diversity and composition, but microbes that inhabit the mouse gut and skin can also influence severity and penetrance of host mut...
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Article
Know Your Model: The role of sex in phenotype penetrance and severity
There’s growing evidence that sex-based differences can influence phenotypes beyond those directly related to the reproductive system; to fully understand a gene’s function, researchers should consider both ma...
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Article
Know Your Model: Recombinase-expressing mice
Recombinase-expressing mice are selected based on where and when they will activate conditional alleles, but some produce phenotypes in isolation that can complicate analysis of those alleles.
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Article
Know Your Model: When parental origin matters
Differential gene expression based on the parental origin can have a big impact on phenotype
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Article
Know Your Model: Why mouse inbred strain contribution matters
Strain contributions arising from the strain of origin and backcrosses can modify phenotypic severity and/or penetrance of mutant alleles in mouse models.
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Article
Know Your Model: A knockout does not always make a null
Creating a null mutation of a gene is a powerful way to examine gene function, but knocking out part of a gene does not always result in a null allele.
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Article
Know Your Model: How essential is that essential gene?
Many studies have reported on the identification of ‘essential genes’ in mice, but the context of the experimental model, including genetic background and specific molecular details of the allele, may impact t...
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Article
Open AccessNaming CRISPR alleles: endonuclease-mediated mutation nomenclature across species
The widespread use of CRISPR/Cas and other targeted endonuclease technologies in many species has led to an explosion in the generation of new mutations and alleles. The ability to generate many different muta...
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Mouse Genome Informatics (MGI): Resources for Mining Mouse Genetic, Genomic, and Biological Data in Support of Primary and Translational Research
The Mouse Genome Informatics (MGI), resource (www.informatics.jax.org) has existed for over 25 years, and over this time its data content, informatics infras...
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Article
Open AccessThe International Mouse Strain Resource (IMSR): cataloging worldwide mouse and ES cell line resources
The availability of and access to quality genetically defined, health-status known mouse resources is critical for biomedical research. By ensuring that mice used in research experiments are biologically, gene...
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Article
Open AccessAllele, phenotype and disease data at Mouse Genome Informatics: improving access and analysis
A core part of the Mouse Genome Informatics (MGI) resource is the collection of mouse mutations and the annotation phenotypes and diseases displayed by mice carrying these mutations. These data are integrated ...
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Article
Global genetic analysis in mice unveils central role for cilia in congenital heart disease
A forward genetic screen in fetal mice to identify genes involved in congenital heart disease (CHD) reveals that a large proportion of genes associated with CHD are related to cilia and cilia-transduced cell s...
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Article
Open AccessExpanding the mammalian phenotype ontology to support automated exchange of high throughput mouse phenoty** data generated by large-scale mouse knockout screens
A vast array of data is about to emerge from the large scale high-throughput mouse knockout phenoty** projects worldwide. It is critical that this information is captured in a standardized manner, made acces...
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Article
Open AccessThe Vertebrate Trait Ontology: a controlled vocabulary for the annotation of trait data across species
The use of ontologies to standardize biological data and facilitate comparisons among datasets has steadily grown as the complexity and amount of available data have increased. Despite the numerous ontologies ...
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Article
Open AccessThe Mammalian Phenotype Ontology as a unifying standard for experimental and high-throughput phenoty** data
The Mammalian Phenotype Ontology (MP) is a structured vocabulary for describing mammalian phenotypes and serves as a critical tool for efficient annotation and comprehensive retrieval of phenotype data. Import...
