32 Result(s)
within
Martin Lacher
Pediatric Surgery
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Article
Experimental congenital diaphragmatic hernia features an alteration of DNA sensing targets cGAS and STING
The pathogenesis of congenital diaphragmatic hernia (CDH) depends on multiple factors. Activation of the DNA-sensing cyclic-GMP-AMP-synthase (cGAS) and Stimulator-of-Interferon-Genes (STING) pathway by double-...
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Article
Characterization of the congenital diaphragmatic hernia model in C57BL/6J fetal mice: a step toward lineage tracing experiments
Lineage tracing is key to study the fate of individual cells and their progeny especially in developmental biology. To conduct these studies, we aimed to establish a reproducible model of CDH in the most commo...
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Article
Testicular descent revisited: a micro-computed tomography study in fetal rats
There is a long history of research dealing with the embryology of the testicular descent. However, important aspects like the role of the gubernaculum and the development of the processus vaginalis peritonei ...
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Article
Tenascin C is dysregulated in hypoplastic lungs of miR-200b−/− mice
We previously demonstrated that absence of miR-200b results in abnormal lung development in congenital diaphragmatic hernia due to imbalance between epithelial and mesenchymal cells. Tenascin C is a highly con...
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Article
Musculoskeletal deformities in children with congenital thoracic malformations: a population-based cohort study
It is unclear if musculoskeletal deformities observed in patients with congenital diaphragmatic hernia (CDH), congenital lung lesion (CLL) and esophageal atresia/tracheoesophageal fistula (EA/TEF) are associat...
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Blunt Abdominal Trauma
Trauma is the leading cause of disability and death in children. Pediatric trauma patients present unique clinical challenges as compared to adults, including different mechanisms of injury, physiologic respon...
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Necrotizing Enterocolitis (NEC)
(NEC) is the most common lethal gastrointestinal (GI) disease in preterm infants worldwide. It is characterized by severe inflammatory response and intestinal necrosis, and may have a different pathogenesis...
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Laparoscopic Thal Fundoplication
Gastroesophageal reflux disease (GERD) especially in neurologically impaired children remains the main indication for anti-reflux surgery in children. Laparoscopic fundoplication is the treatment of choice. Se...
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Laparoscopic Pyloromyotomy
Hypertrophic pyloric stenosis is the main reason for nonbilious vomiting in the first 3 months of life and is diagnosed by ultrasound. Laparoscopic pyloromyotomy is the treatment of choice. Its technique, rele...
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Laparoscopic Resection of Choledochal Cyst with Hepaticojejunostomy
Choledochal cysts (CDCs) are believed to represent a risk factor for the development of neoplasia; the classical clinical triade is a right upper quadrant mass, associated with pain and jaundice. Therefore the...
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Laparoscopic Pyeloplasty
Laparoscopic transabdominal dismembered pyeloplasty for ureteropelvic junction obstruction (UPJO) is effective and safe in infants and children. The indications for laparoscopic pyeloplasty are the same as for...
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Article
Epithelial cell-adhesion protein cadherin 26 is dysregulated in congenital diaphragmatic hernia and congenital pulmonary airway malformation
Congenital diaphragmatic hernia (CDH) and congenital pulmonary airway malformation (CPAM) are two inborn pathologies of the lung of unknown origin. Alterations of gene expression in airway epithelial cells are...
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Laparoscopic Herniorrhaphy
Laparoscopic inguinal hernia repair in children has increased in popularity over the past years. The indications for laparoscopic inguinal hernia repair are the same as for the open approach. Several randomize...
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Laparoscopic Transperitoneal Heminephrectomy
Laparoscopic heminephrectomy (LHN) may be indicated in children with ectopic ureter or vesico-ureteral reflux related to the poorly or non-functioning moiety of a duplex renal system. Preoperative evaluation c...
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Vesicoureteral Reflux (VUR)
Vesicoureteral is the most common disease of the urinary tract in , occurring in 1 to 2% of the population and in 30 to 40% of presenting with a . The familial nature is well recognized. Siblings of ...
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Laparoscopic Varicocelectomy
Varicocele, a collection of abnormally dilatated, tortuous spermatic veins, has a high prevalence in the general male population. It is common in boys and young men and represents one of the most common causes...
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Laparoscopic Toupet Fundoplication
Laparoscopic Toupet fundoplication (LTF) is a minimal access procedure for the surgical management of gastro-esophageal reflux disease (GERD) and has the advantages of being associated with a lower incidence o...
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Pulmonary Sequestrations
Pulmonary Sequestration (PS) consists of lung parenchyma that does not regularly communicate with the normal tracheobronchial tree and is supplied by an aberrant systemic vessel mainly from the thoracic and ab...
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Single-Incision Pediatric Endosurgical (SIPES) Appendectomy using a Glove Port
Pediatric single-incision pediatric endosurgery (SIPES) appendectomy has recently gained popularity due to its advantages over the traditional 3-port approach. In addition to the traditional single port system...
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Laparoscopic Partial Splenectomy
Total splenectomy carries the risk of overwhelming post-splenectomy infection (OPSI) which can occur in up to 4.4% of patients with a mortality rate of 50–80%. Partial splenectomy can prevent post-splenectomy ...
